Department of Clinical Laboratory, The Second Clinical Medical College of Capital Medical University, Beijing Friendship Hospital, Beijing, China,
Department of Clinical Laboratory, The Second Clinical Medical College of Capital Medical University, Beijing Friendship Hospital, Beijing, China.
Med Princ Pract. 2020;29(2):195-200. doi: 10.1159/000502131. Epub 2019 Jul 17.
An association of Epstein-Barr virus (EBV) infection with breast carcinoma (BC) risk has so far been disputed in the literature. Therefore, we performed a meta-analysis to clarify this relationship.
An electronic database search for eligible case-control studies was performed using PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang Data until May 17, 2018. The pooled OR and 95% CI were used to estimate the relationship between EBV infection and BC risk using a fixed or random-effects model depending on heterogeneity. Subgroup analysis and meta-regression were used to explore the heterogeneity. Publication bias was assessed using Egger's and Harbord's tests.
A total of 16 studies with 1,279 patients and 814 controls were reviewed based on our inclusion and exclusion criteria. Compared with the control group, EBV infection had a significant association with BC risk (OR 4.75, 95% CI 2.53-8.92, p < 0.01) with significant heterogeneity observed (I2 = 65.3%). The subgroup analysis revealed that region and tissue type might explain potential sources of heterogeneity. The sensitivity analyses yielded stable results. No significant publication bias was observed.
The current results suggest that EBV infection is significantly associated with increased risk of BC.
目前，文献中关于 EBV 感染与乳腺癌（BC）风险之间的关联仍存在争议。因此，我们进行了一项荟萃分析以阐明这种关系。
使用 PubMed、Embase、Web of Science、Cochrane 图书馆、CNKI 和万方数据对符合条件的病例对照研究进行了电子数据库检索，检索时间截至 2018 年 5 月 17 日。使用固定或随机效应模型（取决于异质性），汇总 OR 和 95％CI 来估计 EBV 感染与 BC 风险之间的关系。使用亚组分析和 meta 回归来探讨异质性。使用 Egger 检验和 Harbord 检验评估发表偏倚。
根据纳入和排除标准，共纳入了 16 项研究，包括 1279 名患者和 814 名对照。与对照组相比，EBV 感染与 BC 风险具有显著相关性（OR 4.75，95％CI 2.53-8.92，p <0.01），且存在显著的异质性（I2 = 65.3％）。亚组分析显示，地区和组织类型可能是异质性的潜在来源。敏感性分析得出了稳定的结果。未发现明显的发表偏倚。
目前的结果表明，EBV 感染与 BC 风险增加显著相关。
