Biomedical Engineering Research Unit, National Metal and Materials Technology Center, Pathum Thani 12120, Thailand.
Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
J Healthc Eng. 2017;2017:9547896. doi: 10.1155/2017/9547896. Epub 2017 Aug 20.
Porous oligolactide-hydroxyapatite composite scaffolds were obtained by stereolithographic fabrication. Gentamicin was then coated on the scaffolds afterwards, to achieve antimicrobial delivery ability to treat bone infection. The scaffolds examined by stereomicroscope, SEM, and CT-scan showed a well-ordered pore structure with uniform pore distribution and pore interconnectivity. The physical and mechanical properties of the scaffolds were investigated. It was shown that not only porosity but also scaffold structure played a critical role in governing the strength of scaffolds. A good scaffold design could create proper orientation of pores in a way to strengthen the scaffold structure. The drug delivery profile of the porous scaffolds was also analyzed using microbiological assay. The release rates of gentamicin from the scaffolds showed prolonged drug release at the levels higher than the minimum inhibitory concentrations for and over a 2-week period. It indicated a potential of the scaffolds to serve as local antibiotic delivery to prevent bacterial infection.
多孔低聚乳酸-羟基磷灰石复合支架通过立体光刻制造获得。然后在支架上涂覆庆大霉素，以实现抗菌药物输送能力，从而治疗骨感染。通过体视显微镜、SEM 和 CT 扫描检查支架，显示出具有均匀孔分布和孔连通性的有序孔结构。研究了支架的物理和机械性能。结果表明，不仅孔隙率，而且支架结构在控制支架强度方面起着关键作用。良好的支架设计可以以适当的方式创建孔的方向，从而增强支架结构。还使用微生物测定法分析了多孔支架的药物释放特性。庆大霉素从支架中的释放率表明，在 2 周的时间内，高于最低抑菌浓度的庆大霉素的药物释放时间延长。这表明支架具有作为局部抗生素输送的潜力，以防止细菌感染。
