Jensen Louise K, Johansen Anne S B, Jensen Henrik E
Section for Experimental Animal Models, Department of Veterinary and Animal Science, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark.
Front Microbiol. 2017 Oct 10;8:1961. doi: 10.3389/fmicb.2017.01961. eCollection 2017.
Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of studies are compared to studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).
细菌生物膜形成是许多人类慢性感染治疗效果不佳和复发率高的主要原因之一。同时研究生物膜形成细菌和宿主反应的最佳方法是使用具有鉴别性、可靠性和可重复性的感染动物模型。在这篇综述中，将研究的优势与传染病中生物膜形成的研究进行了比较。由于猪在解剖学、生理学和免疫系统方面与人类相似，因此在开发和应用大型传染病动物模型时，猪是首选动物。此外，普通猪会自发患上许多与人类相同的慢性细菌感染。因此，在这篇综述中，描述了五种不同传染病的猪模型，这些疾病都与人类的生物膜形成和慢性感染有关。这些传染病是：慢性伤口、心内膜炎、肾盂肾炎、血源性骨髓炎和植入物相关骨髓炎（IAO）。
