Molinuevo José Luis, Gramunt Nina, Gispert Juan Domingo, Fauria Karine, Esteller Manel, Minguillon Carolina, Sánchez-Benavides Gonzalo, Huesa Gema, Morán Sebastián, Dal-Ré Rafael, Camí Jordi
Barcelonaβeta Brain Research Center, Barcelona, Spain.
Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Alzheimers Dement (N Y). 2016 Mar 3;2(2):82-92. doi: 10.1016/j.trci.2016.02.003. eCollection 2016 Jun.
The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA registry and parent cohort and the nested ALFA+ cohort study.
The ALFA parent cohort baseline visit included full cognitive evaluation, lifestyle habits questionnaires, DNA extraction, and MRI. The nested ALFA+ study adds wet and imaging biomarkers for deeper phenotyping.
A total of 2743 participants aged 45 to 74 years were included in the ALFA parent cohort. We show that this cohort, mostly composed of cognitively normal offspring of AD patients, is enriched for AD genetic risk factors.
The ALFA project represents a valuable infrastructure that will leverage with different studies and trials to prevent AD. The longitudinal ALFA+ cohort will serve to untangle the natural history of the disease and to model the preclinical stages to develop successful trials.
阿尔茨海默病（AD）的临床前阶段最适合识别早期病理生理事件并制定预防方案，这是ALFA项目的共同目标，该项目包括ALFA登记册和母体队列以及嵌套的ALFA+队列研究。
ALFA母体队列基线访视包括全面认知评估、生活习惯问卷、DNA提取和MRI。嵌套的ALFA+研究增加了生物标志物检测和影像学检查以进行更深入的表型分析。
共有2743名年龄在45至74岁之间的参与者纳入了ALFA母体队列。我们发现，该队列主要由AD患者的认知正常后代组成，富含AD遗传风险因素。
ALFA项目是一个有价值的基础设施，将与不同的研究和试验合作以预防AD。纵向的ALFA+队列将有助于理清疾病的自然史，并为临床前阶段建模以开展成功的试验。
