Ali Ali M, Wang Wei-Lien, Lazar Alexander J
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
J Cutan Pathol. 2018 Feb;45(2):146-150. doi: 10.1111/cup.13067. Epub 2017 Dec 6.
Melanoma can rarely show malignant chondro-osseous differentiation and can cause diagnostic confusion. We report 3 cases of primary melanoma with extensive bone and cartilage matrix. The first case arose in the nasal mucosa of a 72-year-old woman, the second case in the left index finger of a 26-year-old woman and the third case in the left cheek of a 68-year-old woman. In tumors where osseous and chondroid differentiation appear in mucosa and skin, primary melanoma with chondro-osteosarcomatous differentiation should be considered in the differential. Careful histological examination together with clinical correlation and ancillary immunohistochemical studies can ensure the correct diagnosis is made.
黑色素瘤很少表现出恶性软骨-骨分化，可导致诊断混淆。我们报告3例具有广泛骨和软骨基质的原发性黑色素瘤。第一例发生在一名72岁女性的鼻黏膜，第二例发生在一名26岁女性的左手食指，第三例发生在一名68岁女性的左脸颊。在黏膜和皮肤中出现骨和软骨样分化的肿瘤中，鉴别诊断时应考虑具有软骨-骨肉瘤样分化的原发性黑色素瘤。仔细的组织学检查、临床相关性分析及辅助免疫组化研究可确保做出正确诊断。
