Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Miyagi 980-8575, Japan.
Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Miyagi 980-8573, Japan.
Nucleic Acids Res. 2018 Jan 4;46(D1):D551-D557. doi: 10.1093/nar/gkx978.
We developed jMorp, a new database containing metabolome and proteome data for plasma obtained from >5000 healthy Japanese volunteers from the Tohoku Medical Megabank Cohort Study, which is available at https://jmorp.megabank.tohoku.ac.jp. Metabolome data were measured by proton nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS), while proteome data were obtained by nanoLC-MS. We released the concentration distributions of 37 metabolites identified by NMR, distributions of peak intensities of 257 characterized metabolites by LC-MS, and observed frequencies of 256 abundant proteins. Additionally, correlation networks for the metabolites can be observed using an interactive network viewer. Compared with some existing databases, jMorp has some unique features: (i) Metabolome data were obtained using a single protocol in a single institute, ensuring that measurement biases were significantly minimized; (ii) The database contains large-scale data for healthy volunteers with various health records and genome data and (iii) Correlations between metabolites can be easily observed using the graphical viewer. Metabolites data are becoming important intermediate markers for evaluating the health states of humans, and thus jMorp is an outstanding resource for a wide range of researchers, particularly those in the fields of medical science, applied molecular biology, and biochemistry.
我们开发了 jMorp，这是一个新的数据库，包含了来自东北医科大学百万基因组研究多组学数据库（Tohoku Medical Megabank Cohort Study）中超过 5000 名日本健康志愿者的血浆代谢组和蛋白质组数据，可在 https://jmorp.megabank.tohoku.ac.jp 上获取。代谢组数据通过质子磁共振（NMR）和液相色谱-质谱（LC-MS）进行测量，而蛋白质组数据则通过纳升液相色谱-质谱（nanoLC-MS）获得。我们发布了通过 NMR 鉴定的 37 种代谢物的浓度分布、通过 LC-MS 鉴定的 257 种特征代谢物的峰强度分布以及 256 种丰富蛋白的观察频率。此外，还可以使用交互式网络查看器观察代谢物的相关网络。与一些现有的数据库相比，jMorp 具有一些独特的特点：（i）代谢组数据是在单个机构中使用单一方案获得的，确保了测量偏差得到了显著的最小化；（ii）数据库包含了来自各种健康记录和基因组数据的大量健康志愿者的大型数据集；（iii）使用图形查看器可以轻松观察代谢物之间的相关性。代谢物数据正在成为评估人类健康状况的重要中间标志物，因此 jMorp 是广泛的研究人员，特别是医学科学、应用分子生物学和生物化学领域的研究人员的优秀资源。
