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美国退伍军人事务部医疗体系中的二尖瓣手术:10 年的结果和趋势。

Mitral valve surgery in the US Veterans Administration health system: 10-year outcomes and trends.

机构信息

Department of Surgery, Baylor College of Medicine, Houston, Tex; The Michael E. DeBakey VA Medical Center, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex; Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio.

Department of Surgery, Stony Brook Medicine, Stony Brook, NY; Research and Development Office, Northport VA Medical Center, Northport, NY.

出版信息

J Thorac Cardiovasc Surg. 2018 Jan;155(1):105-117.e5. doi: 10.1016/j.jtcvs.2017.07.089. Epub 2017 Sep 30.

Abstract

OBJECTIVE

To compare mitral valve repair (MVRepair) and mitral valve replacement (MVReplace) trends in the Veterans Affairs (VA) Surgical Quality Improvement Program.

METHODS

Trends were compared by bivariate analyses, followed by backward stepwise selection and multivariable logistic modeling to determine the effect of preoperative comorbidities and facility-level factors on MVRepair (vs MVReplace) rate. A subgroup analysis focused on patients who underwent elective surgery for isolated primary degenerative mitral regurgitation. Propensity matching was done in the overall and primary degenerative cohorts.

RESULTS

From October 2000 to October 2013, 4165 veterans underwent MVRepair (n = 2408) or MVReplace (n = 1757) for MV disease of any cause at 40 VA medical centers (procedural volume, 0-29/y; median 7/y). The MVRepair percentage increased from 48% in 2001 to 63% in 2013 (P < .001). MVRepair rates varied widely among centers; center volume explained only 19% of this variation after adjustment for case mix (R = 0.19, P = .005). Unadjusted 30-day and 1-year mortality rates were lower after MVRepair than after MVReplace (3.5% vs 4.8%, P = .04; 9.8% vs 12.1%, P = .02). Among the propensity-matched patients (n = 2520), 30-day and 1-year mortality were similar after MVRepair and MVReplace. In the propensity-matched primary degenerative subgroup (n = 664), unadjusted long-term mortality for up to 10 years postoperatively was lower after MVRepair (28% vs 37%, P = .003), as was risk-adjusted long-term mortality (hazard ratio, 0.78; 95% confidence interval, 0.61-1.01).

CONCLUSIONS

In the VA Health System, mortality after MV operations is low. Despite the survival advantage associated with MV repair in primary mitral regurgitation, repair is infrequent at some centers, representing an opportunity for quality improvement.

摘要

目的

比较退伍军人事务部(VA)手术质量改进计划中的二尖瓣修复(MVRepair)和二尖瓣置换(MVReplace)趋势。

方法

通过双变量分析比较趋势,然后进行向后逐步选择和多变量逻辑建模,以确定术前合并症和医疗机构因素对 MVRepair(与 MVReplace 相比)率的影响。亚组分析集中在因原发性退行性二尖瓣反流而接受择期手术的患者。在总体和原发性退行性队列中进行倾向匹配。

结果

2000 年 10 月至 2013 年 10 月,4165 名退伍军人在 40 家 VA 医疗中心因任何原因的二尖瓣疾病接受 MVRepair(n=2408)或 MVReplace(n=1757)治疗(手术量为 0-29/年;中位数为 7 年)。MVRepair 的百分比从 2001 年的 48%增加到 2013 年的 63%(P<0.001)。尽管在调整病例组合后,中心数量仅能解释这种变化的 19%(R=0.19,P=0.005),但中心之间的 MVRepair 率差异很大。校正后,MVRepair 后 30 天和 1 年死亡率低于 MVReplace(3.5%比 4.8%,P=0.04;9.8%比 12.1%,P=0.02)。在匹配倾向的患者(n=2520)中,MVRepair 和 MVReplace 后 30 天和 1 年死亡率相似。在匹配倾向的原发性退行性亚组(n=664)中,术后长达 10 年的校正后长期死亡率,MVRepair 较低(28%比 37%,P=0.003),风险校正后长期死亡率也较低(风险比,0.78;95%置信区间,0.61-1.01)。

结论

在 VA 医疗系统中,二尖瓣手术后的死亡率较低。尽管原发性二尖瓣反流的 MV 修复与生存优势相关,但在某些中心,修复并不常见,这代表了提高质量的机会。

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