Driscoll E J, Gelfman S S, Sweet J B, Butler D P, Wirdzck P R, Medlin T
J Oral Surg. 1979 Nov;37(11):809-15.
A number of technical and clinical conditions reportedly associated with diazepam-related thrombophlebitis were investigated. Diazepam alone and in combination with fentanyl and methohexital was administered intravenously to 519 healthy, predominantly young adult patients undergoing routine oral surgery for removal of third molars. Indirect evidence is provided to show that two slightly different vasculopathies are involved: thrombophlebitis, in which pain and induration are both present but in which there is a slight delay in the time of inception of the condition; and phlebothrombosis, in which the reaction is almost immediate but pain is not significant and induration of the vein is the predominant feature. The overall incidence was 2.3% for thrombophlebitis and 9.8% for phlebothrombosis. There were four significant variables associated with phlebothrombosis: use of tobacco, use of oral contraceptives, multiple injections of diazepam, and pain during injection. The only significant variable associated with thrombophlebitis was the site of injection.
对一些据报道与地西泮相关血栓性静脉炎有关的技术和临床情况进行了调查。将地西泮单独以及与芬太尼和甲己炔巴比妥联合静脉注射给519名主要为年轻成年的健康患者，这些患者正在接受拔除第三磨牙的常规口腔手术。有间接证据表明涉及两种略有不同的血管病变：血栓性静脉炎，疼痛和硬结均存在，但病情开始时间略有延迟；静脉血栓形成，反应几乎立即出现，但疼痛不明显，静脉硬结是主要特征。血栓性静脉炎的总体发生率为2.3%，静脉血栓形成的总体发生率为9.8%。与静脉血栓形成相关的有四个显著变量：吸烟、使用口服避孕药、多次注射地西泮以及注射时疼痛。与血栓性静脉炎相关的唯一显著变量是注射部位。
