Parkes R B, Blanton P L, Thrash W J
Anesth Prog. 1982 Nov-Dec;29(6):168-9.
Forty-one adult males volunteered for a study designed to investigate the thrombogenicity of the Valium® vehicle. Utilizing a standardized protocol, each subject received a sedative dose of Injectable Valium® in the antecubital fossa of one arm and an equivalent volume of vehicle in the contralateral arm. Both were administered with a continuous infusion drip of 5 per cent dextrose in water. Post-operative evaluation extended over 10 weeks and included clinical observation and palpation. Ultrasonic tests for occluded or impaired blood flow were performed with a Doppler Flowmeter.Five subjects (12.2 percent) had venous sequelae with the Valium® and two (4.8 percent) developed sequelae with the vehicle. The incidence of venous sequelae reported in the present study was considerably lower than in previous investigations (66.6 per cent and 37.5 per cent) utilizing the same protocol. The present study indicates that time of continuous infusion appears to contribute to thrombophlebitis subsequent to intravenous injection of Valium®. It also appears that the diazepam vehicle is not the major factor in the occurrence of thrombophlebitis.
41名成年男性自愿参与一项旨在研究安定注射液溶媒血栓形成性的研究。按照标准化方案，每位受试者在一侧手臂的肘前窝接受一剂镇静剂量的注射用安定，在对侧手臂接受等量的溶媒。两者均通过5%葡萄糖水溶液持续静脉滴注给药。术后评估持续10周，包括临床观察和触诊。使用多普勒流量计对血流阻塞或受损情况进行超声检查。5名受试者（12.2%）使用安定后出现静脉后遗症，2名受试者（4.8%）使用溶媒后出现后遗症。本研究报告的静脉后遗症发生率明显低于此前采用相同方案的调查（分别为66.6%和37.5%）。本研究表明，持续输注时间似乎会导致静脉注射安定后发生血栓性静脉炎。似乎地西泮溶媒也不是血栓性静脉炎发生的主要因素。
