Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCVAMC), 10701 East Boulevard, Cleveland, OH 44106, USA; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44195-5029, USA.
Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCVAMC), 10701 East Boulevard, Cleveland, OH 44106, USA; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44195-5029, USA; Specialty Care Center of Innovation, LSCVAMC, 10701 East Boulevard, Cleveland, OH 44106, USA; Research Services, LSCVAMC, 10701 East Boulevard, Cleveland, OH 44106, USA; Department of Pathology, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44195-5029, USA; Department of Pharmacology, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44195-5029, USA; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44195-5029, USA; Department of Biochemistry, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44195-5029, USA.
Infect Dis Clin North Am. 2017 Dec;31(4):593-608. doi: 10.1016/j.idc.2017.07.017.
In older adults, pathophysiologic, clinical, and environmental factors all affect the presentation of infections. We explore how age-related changes influence the manifestation and evaluation of infections in this population. Specific topics include immunosenescence, age-related organ-specific physiologic changes, and frailty. We also describe clinical factors influencing infection risk and presentation in older adults, including temperature regulation, cognitive decline, and malnutrition. Finally, we discuss the influence of the setting in which older adults reside on the clinical evaluation of infection. Understanding the influence of all these changes may facilitate the prevention, early recognition, and treatment of infections in older adults.
在老年人中，病理生理、临床和环境因素都会影响感染的表现。我们探讨了与年龄相关的变化如何影响这一人群感染的表现和评估。具体主题包括免疫衰老、与年龄相关的特定器官生理性变化和虚弱。我们还描述了影响老年人感染风险和表现的临床因素，包括体温调节、认知能力下降和营养不良。最后，我们讨论了老年人居住环境对感染临床评估的影响。了解所有这些变化的影响可能有助于预防、早期识别和治疗老年人的感染。
