Fielding R A, Travison T G, Kirn D R, Koochek A, Reid K F, von Berens Å, Zhu H, Folta S C, Sacheck J M, Nelson M E, Liu C K, Åberg A C, Nydahl M, Lilja M, Gustafsson T, Cederholm T
Roger A. Fielding, Ph.D., Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA. Phone: (617) 556-3016.Email:
J Nutr Health Aging. 2017;21(9):936-942. doi: 10.1007/s12603-017-0936-x.
The interactions between nutritional supplementation and physical activity on changes in physical function among older adults remain unclear. The primary objective of this study was to examine the impact of nutritional supplementation plus structured physical activity on 400M walk capacity in mobility-limited older adults across two sites (Boston, USA and Stockholm, Sweden).
All subjects participated in a physical activity program (3x/week for 24 weeks), involving walking, strength, balance, and flexibility exercises. Subjects were randomized to a daily nutritional supplement (150kcal, 20g whey protein, 800 IU vitamin D) or placebo (30kcal, non-nutritive).
Participants were recruited from urban communities at 2 field centers in Boston MA USA and Stockholm SWE.
Mobility-limited (Short Physical Performance Battery (SPPB) ≤9) and vitamin D insufficient (serum 25(OH) D 9 - 24 ng/ml) older adults were recruited for this study.
Primary outcome was gait speed assessed by the 400M walk.
149 subjects were randomized into the study (mean age=77.5±5.4; female=46.3%; mean SPPB= 7.9±1.2; mean 25(OH)D=18.7±6.4 ng/ml). Adherence across supplement and placebo groups was similar (86% and 88%, respectively), and was also similar across groups for the physical activity intervention (75% and 72%, respectively). Both groups demonstrated an improvement in gait speed with no significant difference between those who received the nutritional supplement compared to the placebo (0.071 and 0.108 m/s, respectively (p=0.06)). Similar effects in physical function were observed using the SPPB. Serum 25(OH)D increased in supplemented group compared to placebo 7.4 ng/ml versus 1.3 ng/ml respectively.
Results suggest improved gait speed following physical activity program with no further improvement with added nutritional supplementation.
营养补充与体育活动对老年人身体功能变化的相互作用尚不清楚。本研究的主要目的是考察营养补充剂加结构化体育活动对两个地点（美国波士顿和瑞典斯德哥尔摩）行动受限的老年人400米步行能力的影响。
所有受试者都参加了一项体育活动计划（每周3次，共24周），包括步行、力量、平衡和柔韧性练习。受试者被随机分为每日营养补充剂组（150千卡、20克乳清蛋白、800国际单位维生素D）或安慰剂组（30千卡，无营养）。
参与者是从美国马萨诸塞州波士顿和瑞典斯德哥尔摩的2个现场中心的城市社区招募的。
招募行动受限（简短身体机能测试（SPPB）≤9）且维生素D不足（血清25（OH）D 9 - 24纳克/毫升）的老年人参与本研究。
主要结局是通过400米步行评估的步态速度。
149名受试者被随机纳入研究（平均年龄 = 77.5±5.4；女性 = 46.3%；平均SPPB = 7.9±1.2；平均25（OH）D = 18.7±6.4纳克/毫升）。补充剂组和安慰剂组的依从性相似（分别为86%和88%），体育活动干预在各组之间也相似（分别为75%和72%）。两组的步态速度均有所改善，接受营养补充剂的人与接受安慰剂的人之间无显著差异（分别为0.071和0.108米/秒（p = 0.06））。使用SPPB观察到身体功能有类似效果。与安慰剂组相比，补充剂组的血清25（OH）D有所增加，分别为7.4纳克/毫升和1.3纳克/毫升。
结果表明，体育活动计划后步态速度有所改善，添加营养补充剂后无进一步改善。
