Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala Science Park, 751 85, Uppsala, Sweden.
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
BMC Geriatr. 2018 Nov 21;18(1):286. doi: 10.1186/s12877-018-0976-z.
Health-related quality of life (HRQoL) and absence of depressive symptoms are of great importance for older people, which may be achieved through lifestyle interventions, e.g., exercise and nutrition interventions. The aim of this investigation was to analyze the effects of a physical activity program in combination with protein supplementation on HRQoL and depressive symptoms in community-dwelling, mobility-limited older adults.
In the Vitality, Independence, and Vigor 2 Study (VIVE2), community-dwelling men and women with an average age of 77.5 ± 5.4 years, some mobility limitations and low serum vitamin D levels (25(OH)Vit D 22.5-60 nmol/l) from two study sites (Stockholm, Sweden and Boston, USA) were randomized to receive a nutritional supplement or a placebo for 6 months. All took part in a physical activity program 2-3 times/ week. The primary outcome examined in VIVE2 was 400 M walk capacity. HRQoL was measured using the Medical Outcomes Study 36-item Short Form Health Survey (SF36), consisting of the Physical Component Summary (PCS) and Mental Component Summary (MCS), and depressive symptoms were measured using The Centre for Epidemiologic Studies Depression Scale (CES-D). In the sensitivity analyses, the sample was divided into sub-groups based on body measures and function (body mass index (BMI), appendicular lean mass index (ALMI), handgrip strength and gait speed).
For the whole sample, there was a significant improvement in both MCS, mean (95% CI) 2.68 (0.5, 4.9) (p 0.02), and CES-D -2.7 (- 4.5, - 0.9) (p 0.003) during the intervention, but no difference was detected between those who received the nutritional supplement and those who received the placebo. The results revealed no significant change in PCS or variation in effects across the sub-categories.
This study demonstrates that a six-month intervention using a physical activity program had positive effects on mental status. No additional effects from nutritional supplementation were detected.
Registered at ClinicalTrials.gov, March 2 2012, NCT01542892 .
健康相关生活质量（HRQoL）和无抑郁症状对老年人非常重要，这可以通过生活方式干预来实现，例如运动和营养干预。本研究的目的是分析一项体育活动计划与蛋白质补充相结合对社区居住、行动受限的老年人的 HRQoL 和抑郁症状的影响。
在活力、独立和活力 2 研究（VIVE2）中，来自两个研究地点（瑞典斯德哥尔摩和美国波士顿）的平均年龄为 77.5±5.4 岁、有一定活动能力限制和低血清维生素 D 水平（25(OH)Vit D 22.5-60nmol/l）的社区居住男性和女性被随机分配接受营养补充剂或安慰剂治疗 6 个月。所有人都每周进行 2-3 次体育活动。VIVE2 的主要观察指标是 400 米步行能力。使用医疗结局研究 36 项简短健康调查问卷（SF36）测量 HRQoL，包括身体成分综合评分（PCS）和心理成分综合评分（MCS），使用流行病学研究中心抑郁量表（CES-D）测量抑郁症状。在敏感性分析中，根据身体测量和功能（体重指数（BMI）、四肢瘦体重指数（ALMI）、握力和步态速度）将样本分为亚组。
对于整个样本，在干预期间，MCS 显著改善，平均（95%CI）2.68（0.5，4.9）（p 0.02），CES-D 降低-2.7（-4.5，-0.9）（p 0.003），但营养补充组与安慰剂组之间无差异。结果显示 PCS 无显著变化，各亚类的效应也无差异。
本研究表明，为期 6 个月的体育活动计划干预对精神状态有积极影响。未发现营养补充的额外效果。
于 2012 年 3 月 2 日在 ClinicalTrials.gov 注册，NCT01542892。
