Wang Na, Fang Hong, Fu Chaowei, Huang Peixin, Su Meifang, Jiang Feng, Zhao Qi, Chen Yue, Jiang Qingwu
Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Department of Chronic Disease Control and Prevention, Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.
BMJ Open. 2017 Oct 30;7(10):e016706. doi: 10.1136/bmjopen-2017-016706.
Obesity has been found to be associated with an elevated risk of thyroid nodule(s), mainly in adults; however, evidence for this association in children was limited. The objective of this study was to investigate the association of adiposity and thyroid nodule(s) in children living in iodine-sufficiency areas.
We conducted a cross-sectional study of 1403 Chinese children living in the East Coast of China in 2014.
Anthropometric measures including height, weight and waist and hip circumferences were taken, and body mass index (BMI), body surface area (BSA) and waist-hip ratio (WHR) were then calculated. Thyroid ultrasonography was performed to assess thyroid volume and nodules.
Based on BMI, 255 (18.17%) children were overweight and 174 (12.40%) were obese. Thyroid nodule(s) was detected in 18.46% of all participants and showed little age and sex variations. As compared with normal-weight children, obese children experienced significantly higher risks for solitary (OR 2.07 (95% CI 1.16 to 3.71)) and multiple (OR 1.67 (95% CI 1.03 to 2.70)) thyroid nodules. Similar associations with thyroid nodule(s) were observed with adiposity measured by waist circumference and BSA, but not WHR. There were no notable differences in the associations between children consuming iodised and non-iodised salt.
These findings provide further evidence that childhood obesity is associated with the risk for thyroid nodule(s).
肥胖已被发现与甲状腺结节风险升高有关，主要见于成年人；然而，儿童中这种关联的证据有限。本研究的目的是调查碘充足地区儿童肥胖与甲状腺结节之间的关联。
2014年，我们对居住在中国东海岸的1403名中国儿童进行了一项横断面研究。
测量身高、体重、腰围和臀围等人体测量指标，然后计算体重指数（BMI）、体表面积（BSA）和腰臀比（WHR）。进行甲状腺超声检查以评估甲状腺体积和结节。
根据BMI，255名（18.17%）儿童超重，174名（12.40%）儿童肥胖。在所有参与者中，18.46%检测到甲状腺结节，且年龄和性别差异不大。与体重正常的儿童相比，肥胖儿童出现单发（比值比2.07（95%置信区间1.16至3.71））和多发（比值比1.67（95%置信区间1.03至2.70））甲状腺结节的风险显著更高。通过腰围和BSA测量的肥胖与甲状腺结节也有类似关联，但与WHR无关。食用加碘盐和未加碘盐的儿童之间的关联没有显著差异。
这些发现进一步证明儿童肥胖与甲状腺结节风险有关。
