Fang Jun, Tang Mei
Division of Nephrology, Department of Internal Medicine, Xianning Central Hospital and The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Infusion Preparation Center of the Pharmacy Department, Xianning Central Hospital and The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Biomed Rep. 2017 Oct;7(4):337-342. doi: 10.3892/br.2017.972. Epub 2017 Aug 25.
The prevalence of metabolic syndrome and cardiovascular disease is increasing due to increases in the consumption of high fat diets (HFDs) and the epidemic of obesity. In the present study, it was hypothesized that swimming exercise may prevent HFD-induced impairment of aortic function and that these changes are associated with reduction of oxidative stress, proinflammatory adipokines/cytokines. Male, 6-week-old C57BL/6J mice were fed a 60% lipid composition HFD with or without swimming exercise (90 min/swim and 2 swims/day) for 16 weeks. Exercise training prevented HFD-induced increases in visceral fat weight, total cholesterol and triglycerides. Furthermore, exercise training improved HFD-impaired aortic endothelium-dependent dilation that was associated with reduction of oxidative stress, leptin, resistin, monocyte chemoattractant protein 1, interleukin (IL)6 and IL8. In addition, exercise inhibited HFD-induced vascular endothelial growth factor expression in gastrocnemius skeletal muscle. These data demonstrate that swimming exercise prevents aortic tissue oxidative stress, inflammation and vascular dysfunction in HFD-induced obesity.
由于高脂饮食（HFD）摄入量的增加和肥胖症的流行，代谢综合征和心血管疾病的患病率正在上升。在本研究中，我们假设游泳运动可能预防HFD诱导的主动脉功能损害，并且这些变化与氧化应激、促炎脂肪因子/细胞因子的减少有关。6周龄雄性C57BL/6J小鼠喂食含60%脂质成分的HFD，有或没有游泳运动（每次游泳90分钟，每天2次），持续16周。运动训练可预防HFD诱导的内脏脂肪重量、总胆固醇和甘油三酯增加。此外，运动训练改善了HFD损害的主动脉内皮依赖性舒张，这与氧化应激、瘦素、抵抗素、单核细胞趋化蛋白1、白细胞介素（IL）6和IL8的减少有关。此外，运动抑制了HFD诱导的腓肠肌骨骼肌中血管内皮生长因子的表达。这些数据表明，游泳运动可预防HFD诱导的肥胖症中的主动脉组织氧化应激、炎症和血管功能障碍。
