Theory, simulations, and experiments show that proteins fold by multiple pathways.
作者信息
Eaton William A, Wolynes Peter G
机构信息
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
Department of Chemistry, Rice University, Houston, TX 77005;
出版信息
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9759-E9760. doi: 10.1073/pnas.1716444114. Epub 2017 Oct 30.
Abstract
摘要
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Clash between energy landscape theory and foldon-dependent protein folding.能量景观理论与折叠子依赖性蛋白质折叠之间的冲突。
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8442-8443. doi: 10.1073/pnas.1709133114. Epub 2017 Jul 26.
2
The case for defined protein folding pathways.定义蛋白质折叠途径的理由。
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8253-8258. doi: 10.1073/pnas.1706196114. Epub 2017 Jun 19.
3
Microscopic interpretation of folding ϕ-values using the transition path ensemble.使用过渡路径系综对折叠φ值进行微观解释。
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3263-8. doi: 10.1073/pnas.1520864113. Epub 2016 Mar 8.
4
Single-molecule chemo-mechanical unfolding reveals multiple transition state barriers in a small single-domain protein.单分子化学机械解折叠揭示了一种小单结构域蛋白中的多个过渡态屏障。
Nat Commun. 2015 Apr 17;6:6861. doi: 10.1038/ncomms7861.
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Comparing a simple theoretical model for protein folding with all-atom molecular dynamics simulations.比较蛋白质折叠的简单理论模型与全原子分子动力学模拟。
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17880-5. doi: 10.1073/pnas.1317105110. Epub 2013 Oct 15.
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Force as a single molecule probe of multidimensional protein energy landscapes.力作为一种单分子探针，用于探测多维蛋白质能量景观。
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Chemical physics of protein folding.蛋白质折叠的化学物理学
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