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Theory, simulations, and experiments show that proteins fold by multiple pathways.

作者信息

Eaton William A, Wolynes Peter G

机构信息

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

Department of Chemistry, Rice University, Houston, TX 77005;

出版信息

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9759-E9760. doi: 10.1073/pnas.1716444114. Epub 2017 Oct 30.

DOI:10.1073/pnas.1716444114
PMID:29087352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5699098/
Abstract
摘要

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本文引用的文献

1
Clash between energy landscape theory and foldon-dependent protein folding.能量景观理论与折叠子依赖性蛋白质折叠之间的冲突。
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8442-8443. doi: 10.1073/pnas.1709133114. Epub 2017 Jul 26.
2
The case for defined protein folding pathways.定义蛋白质折叠途径的理由。
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8253-8258. doi: 10.1073/pnas.1706196114. Epub 2017 Jun 19.
3
Microscopic interpretation of folding ϕ-values using the transition path ensemble.使用过渡路径系综对折叠φ值进行微观解释。
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3263-8. doi: 10.1073/pnas.1520864113. Epub 2016 Mar 8.
4
Single-molecule chemo-mechanical unfolding reveals multiple transition state barriers in a small single-domain protein.单分子化学机械解折叠揭示了一种小单结构域蛋白中的多个过渡态屏障。
Nat Commun. 2015 Apr 17;6:6861. doi: 10.1038/ncomms7861.
5
Comparing a simple theoretical model for protein folding with all-atom molecular dynamics simulations.比较蛋白质折叠的简单理论模型与全原子分子动力学模拟。
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17880-5. doi: 10.1073/pnas.1317105110. Epub 2013 Oct 15.
6
Native contacts determine protein folding mechanisms in atomistic simulations.天然接触决定原子模拟中的蛋白质折叠机制。
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17874-9. doi: 10.1073/pnas.1311599110. Epub 2013 Oct 15.
7
Force as a single molecule probe of multidimensional protein energy landscapes.力作为一种单分子探针，用于探测多维蛋白质能量景观。
Curr Opin Struct Biol. 2013 Feb;23(1):48-57. doi: 10.1016/j.sbi.2012.11.007. Epub 2012 Dec 30.
8
Chemical physics of protein folding.蛋白质折叠的化学物理学
Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17770-1. doi: 10.1073/pnas.1215733109. Epub 2012 Oct 29.
9
Prediction of native-state hydrogen exchange from perfectly funneled energy landscapes.从完全漏斗形能量景观预测天然状态氢交换。
J Am Chem Soc. 2011 Nov 2;133(43):17463-72. doi: 10.1021/ja207506z. Epub 2011 Oct 6.
10
Funnels, pathways, and the energy landscape of protein folding: a synthesis.蛋白质折叠的漏斗、途径及能量景观：综述
Proteins. 1995 Mar;21(3):167-95. doi: 10.1002/prot.340210302.