Cowling Benjamin J, Xu Cuiling, Tang Fenyang, Zhang Jun, Shen Jinjin, Havers Fiona, Wendladt Rachael, Leung Nancy Hl, Greene Carolyn, Iuliano A Danielle, Shifflett Pat, Song Ying, Zhang Ran, Kim Lindsay, Chen Yuyun, Chu Daniel Kw, Zhu Huachen, Shu Yuelong, Yu Hongjie, Thompson Mark G
WHO Collaborating Centre for Infectious Disease Epidemiology and Control, Li Ka Shing Faculty of Medicine, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, China.
BMJ Open. 2017 Nov 1;7(10):e017503. doi: 10.1136/bmjopen-2017-017503.
This study was established to provide direct evidence on the incidence of laboratory-confirmed influenza virus and respiratory syncytial virus (RSV) infections in older adults in two cities in Jiangsu Province, China, and the potential impact of acute respiratory infections on frailty.
The cohort was enrolled in Suzhou and Yancheng, two cities in Jiangsu Province in Eastern China. Between November 2015 and March 2016, we enrolled 1532 adults who were 60-89 years of age, and collected blood samples along with baseline data on demographics, general health, chronic diseases, functional status and cognitive function through face-to-face interviews using a standardised questionnaire. Participants are being followed weekly throughout the year to identify acute respiratory illnesses. We schedule home visits to ill participants to collect mid-turbinate nasal and oropharyngeal swabs for laboratory testing and detailed symptom information for the acute illness. Regular follow-up including face-to-face interviews and further blood draws will take place every 6-12 months.
As of 3 September 2016, we had identified 339 qualifying acute respiratory illness events and 1463 (95%) participants remained in the study. Laboratory testing is ongoing.
We plan to conduct laboratory testing to estimate the incidence of influenza virus and RSV infections in older adults. We plan to investigate the impact of these infections on frailty and functional status to determine the association of pre-existing immune status with protection against influenza and RSV infection in unvaccinated older adults, and to assess the exposure to avian influenza viruses in this population.
本研究旨在提供直接证据，以了解中国江苏省两个城市老年人中实验室确诊的流感病毒和呼吸道合胞病毒（RSV）感染的发生率，以及急性呼吸道感染对衰弱的潜在影响。
该队列在中国东部江苏省的苏州和盐城招募。2015年11月至2016年3月期间，我们招募了1532名60-89岁的成年人，并通过使用标准化问卷进行面对面访谈，收集了血液样本以及有关人口统计学、总体健康状况、慢性病、功能状态和认知功能的基线数据。全年每周对参与者进行随访，以确定急性呼吸道疾病。我们安排对患病参与者进行家访，收集中鼻甲鼻拭子和口咽拭子进行实验室检测，并收集急性疾病的详细症状信息。每6-12个月进行一次包括面对面访谈和进一步抽血的定期随访。
截至2016年9月3日，我们已确定339起符合条件的急性呼吸道疾病事件，1463名（95%）参与者仍在研究中。实验室检测正在进行中。
我们计划进行实验室检测，以估计老年人中流感病毒和RSV感染的发生率。我们计划调查这些感染对衰弱和功能状态的影响，以确定未接种疫苗的老年人中预先存在的免疫状态与预防流感和RSV感染的保护作用之间的关联，并评估该人群中禽流感病毒的暴露情况。
