Kellesarian S V, Malignaggi V R, Kellesarian T V, Bashir Ahmed H, Javed F
Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA.
Department of General Dentistry, Dental School, Santa Maria University, Caracas, Venezuela.
Int J Oral Maxillofac Surg. 2018 Feb;47(2):241-251. doi: 10.1016/j.ijom.2017.10.010. Epub 2017 Oct 31.
Implant surface modification has been used to improve osseointegration. However, evidence regarding improved new bone formation (NBF) and osseointegration with the use of collagen-chondroitin sulfate (CS) matrix coated implants remains unclear. The aim of this study was to assess the efficacy of collagen-CS matrix coating on the osseointegration of implants. The focused question was "Does the incorporation of collagen-CS matrix in implant surfaces influence osseointegration?" To answer the question, indexed databases were searched up to July 2017 using various combinations of the key words "collagen", "chondroitin sulfate", "osseointegration", and "implants". The initial literature search identified 497 articles, of which 18 reporting experimental studies fulfilled the inclusion criteria. Thirteen of the studies included (72%) reported that implants coated with a collagen-CS matrix presented higher NBF, bone-to-implant contact, and/or bone volume density. The strength of this observation was supported by meta-analysis results. Nevertheless, the results should be interpreted with caution due to the lack of standardization regarding the dosage formulation of collagen-CS, short-term follow-up, and lack of assessment of confounders. On experimental grounds, the incorporation of collagen-CS matrix into implant surfaces appears to promote osseointegration. From a clinical perspective, the results from animal models support phase I studies in healthy humans.
种植体表面改性已被用于改善骨结合。然而，关于使用硫酸软骨素-胶原蛋白（CS）基质涂层种植体改善新骨形成（NBF）和骨结合的证据仍不明确。本研究的目的是评估胶原蛋白-CS基质涂层对种植体骨结合的疗效。重点问题是“在种植体表面加入胶原蛋白-CS基质是否会影响骨结合？”为了回答这个问题，截至2017年7月使用关键词“胶原蛋白”、“硫酸软骨素”、“骨结合”和“种植体”的各种组合在索引数据库中进行了检索。初步文献检索确定了497篇文章，其中18篇报道实验研究符合纳入标准。纳入研究中的13项（72%）报道，涂有胶原蛋白-CS基质的种植体具有更高的NBF、骨与种植体接触和/或骨体积密度。荟萃分析结果支持了这一观察结果的强度。然而由于胶原蛋白-CS剂量配方缺乏标准化、随访时间短以及未评估混杂因素，对结果的解释应谨慎。基于实验，在种植体表面加入胶原蛋白-CS基质似乎能促进骨结合。从临床角度来看，动物模型的结果支持在健康人群中开展I期研究。
