Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech) , Nanjing 211800, P. R. China.
Department of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital, Medical School, Southeast University , Nanjing 210009, P. R. China.
ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40077-40086. doi: 10.1021/acsami.7b13421. Epub 2017 Nov 9.
TiC MXene is a new two-dimensional material exhibiting a variety of novel properties including good photothermal effect, and the capability of TiC for multimodal tumor therapy is in urgent need of development. Herein, ultrathin TiC MXene nanosheets (∼100 nm) have been synthesized by supplying additive Al to avoid Al loss and employed as a photothermal/photodynamic agent for cancer therapy. The as-obtained nanosheets exhibit outstanding mass extinction coefficient (28.6 Lg cm at 808 nm), superior photothermal conversion efficiency (∼58.3%), and effective singlet oxygen generation (O) upon 808 nm laser irradiation. Based on these TiC nanosheets, a multifunctional nanoplatform (TiC-DOX) is established via layer-by-layer surface modification with doxorubicin (DOX) and hyaluronic acid (HA). In vitro and in vivo experiments disclose that TiC-DOX shows enhanced biocompatibility, tumor specific accumulation, and stimuli-responsive drug release behavior and achieve effective cancer cell killing and tumor tissue destruction through photothermal/photodynamic/chemo synergistic therapy.
TiC MXene 是一种新型二维材料，具有多种新颖的性质，包括良好的光热效应，TiC 用于多模态肿瘤治疗的能力亟待开发。在此，通过添加 Al 来供应添加剂 Al 以避免 Al 损失，并将超薄 TiC MXene 纳米片（∼100nm）用作癌症治疗的光热/光动力剂。所获得的纳米片表现出出色的质量消光系数（在 808nm 处为 28.6Lgcm），优越的光热转换效率（∼58.3%），并在 808nm 激光照射下有效产生单线态氧（O）。基于这些 TiC 纳米片，通过层层表面修饰与阿霉素（DOX）和透明质酸（HA），建立了多功能纳米平台（TiC-DOX）。体外和体内实验揭示了 TiC-DOX 表现出增强的生物相容性、肿瘤特异性积累和刺激响应性药物释放行为，并通过光热/光动力/化疗协同治疗实现有效的癌细胞杀伤和肿瘤组织破坏。
