马比木宁A - E，来自马比木的结构多样的单萜吲哚生物碱。
Mappianines A-E, structurally diverse monoterpenoid indole alkaloids from Mappianthus iodoides.
作者信息
Zhang Gui-Jie, Hu Feng, Jiang Huan, Dai Lu-Mei, Liao Hai-Bing, Li Ning, Wang Heng-Shan, Pan Ying-Ming, Liang Dong
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China; College of Pharmacy, Guilin Medical University, Guilin 541004, People's Republic of China.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
出版信息
Phytochemistry. 2018 Jan;145:68-76. doi: 10.1016/j.phytochem.2017.10.009. Epub 2017 Nov 5.
Five previously undescribed monoterpenoid indole alkaloids, mappianines A-E, along with twelve known analogues, were isolated from the stems of Mappianthus iodoides Hand.-Mazz. Their structures and absolute configurations were determined by spectroscopic analysis, single-crystal X-ray diffraction, and ECD calculations. The plausible biogenetic pathway of mappianine A was proposed. All the isolated compounds were evaluated for their cytotoxic effects on MGC-803, Bel-7404, A549, NCI-H460, and HepG2 cancer cell lines. Mappianine B, tetrahydroalstonine, β-carbolin-1-one, and 1,2,3,4-tetrahydronorharman-1-one displayed moderate cytotoxicity against all cell lines tested, with IC values ranging from 5.19 to 42.86 μM.
从马尾树（Mappianthus iodoides Hand.-Mazz.）的茎中分离出了5个新的单萜吲哚生物碱，即马比宁A-E，以及12个已知类似物。通过光谱分析、单晶X射线衍射和ECD计算确定了它们的结构和绝对构型。提出了马比宁A可能的生源合成途径。对所有分离得到的化合物进行了对MGC-803、Bel-7404、A549、NCI-H460和HepG2癌细胞系的细胞毒性评估。马比宁B、四氢鸭脚木碱、β-咔啉-1-酮和1,2,3,4-四氢去甲哈尔满-1-酮对所有测试细胞系均显示出中等细胞毒性，IC值范围为5.19至42.86 μM。
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