Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Madrid, Spain.
Food Funct. 2018 Jan 24;9(1):78-86. doi: 10.1039/c7fo01280b.
The aim of this study was to examine the effect of a pepsin egg white hydrolysate (EWH) on metabolic complications using a high-fat/high-dextrose diet-induced Metabolic Syndrome (MetS) experimental model. Male Wistar rats were divided into 4 groups which received: standard diet and water (C), standard diet and a solution with 1 g kg day of EWH (CH), high-fat/high-dextrose diet and water (MS), and high-fat/high-dextrose diet and a solution with 1 g kg day of EWH (MSH). EWH consumption normalized body weight gain; abdominal obesity and peripheral neuropathy developed in MetS animals, and adipose tissue and liver weight, as well as plasma glucose were reduced. Oxidative stress and inflammation biomarkers were normalized in MSH animals. In conclusion, the oral administration of EWH could be used as a functional food ingredient to improve some complications associated with MetS induced by unhealthy diets.
本研究旨在使用高脂肪/高葡萄糖饮食诱导的代谢综合征（MetS）实验模型，研究胃蛋白酶蛋清水解物（EWH）对代谢并发症的影响。雄性 Wistar 大鼠分为 4 组，分别给予：标准饮食和水（C）、标准饮食和 1 g/kg/天 EWH 溶液（CH）、高脂肪/高葡萄糖饮食和水（MS）、以及高脂肪/高葡萄糖饮食和 1 g/kg/天 EWH 溶液（MSH）。EWH 可使体重增加正常化；MS 动物发生腹部肥胖和周围神经病变，脂肪组织和肝脏重量以及血浆葡萄糖降低。MSH 动物的氧化应激和炎症生物标志物恢复正常。综上所述，口服 EWH 可作为功能性食品成分，改善不健康饮食引起的代谢综合征相关的一些并发症。
