College of Information Science and Engineering, Northeastern University, Shenyang, 110819, China.
Lab Chip. 2017 Dec 19;18(1):57-74. doi: 10.1039/c7lc00641a.
Photonic crystal (PC) cavities, which possess the advantages of compactness, flexible design, and suitability for integration in a lab-on-a-chip system, are able to distinguish slight variations in refractive index with only a small amount of analyte. Combined with the newly proposed optofluidic technology, PC-cavity devices stimulate an emerging class of miniaturized and label-free biochemical sensors. In this review, an overview of optofluidic PC cavities based biochemical sensors is presented. First, the basic properties of the PC, as well as the sensing principle of the PC cavity, are discussed. Second, the applications of the sensors in detecting gas, liquid, and biomolecule concentrations are reviewed, with a focus on their structures, sensing principles, sensing properties, advantages, and disadvantages. Finally, the current challenges and future development directions of optofluidic PC-cavity-based biochemical sensors are discussed.
光子晶体（PC）腔具有紧凑、灵活设计和适合集成在微流控芯片系统的优点，仅需少量分析物就能区分微小的折射率变化。结合新提出的光电流体技术，PC 腔器件激发了一类新兴的小型化和无标记生物化学传感器。在这篇综述中，介绍了基于光流体 PC 腔的生物化学传感器的概述。首先，讨论了 PC 的基本特性以及 PC 腔的传感原理。其次，综述了传感器在检测气体、液体和生物分子浓度方面的应用，重点介绍了它们的结构、传感原理、传感特性、优点和缺点。最后，讨论了基于光流体 PC 腔的生物化学传感器的当前挑战和未来发展方向。
