Barouki Robert
Inserm UMR-S 1124, Centre universitaire des Saints-Pères, université Paris-Descartes, 45, rue des Saints-Pères, 75006 Paris, France; Service de biochimie métabolomique et protéomique, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France.
C R Biol. 2017 Sep-Oct;340(9-10):410-413. doi: 10.1016/j.crvi.2017.07.005.
During the last decades, a large number of observations have shown that some exogenous substances could interfere with hormone levels or hormone action and could induce toxic effects. This has led to the identification of endocrine disruptors more than 25 years ago as a new class of toxic agents (Zoeller et al., 2014). Those widely used agents correspond to a variety of chemical classes, are not identified by their chemical structure or by a specific type of usage, but rather by their mechanisms of action; this is not unprecedented in toxicology since genotoxicants have also been identified by their mechanism of action, i.e. their ability to alter DNA structure and function.
在过去几十年中，大量观察结果表明，一些外源性物质可能干扰激素水平或激素作用，并可能诱发毒性效应。这导致在25多年前将内分泌干扰物确定为一类新的有毒物质（佐勒尔等人，2014年）。那些广泛使用的物质对应于多种化学类别，不是通过其化学结构或特定使用类型来识别，而是通过其作用机制来识别；这在毒理学中并非没有先例，因为遗传毒性物质也是通过其作用机制，即改变DNA结构和功能的能力来识别的。
