A-to-I RNA 编辑在癌症发展中的作用。
The role of A-to-I RNA editing in cancer development.
机构信息
Department of Pathophysiology, College of Basic Medicine Science, China Medical University, Shenyang, Liaoning Province 110122, China; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Graduate Program in Quantitative and Computational Biosciences and Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Curr Opin Genet Dev. 2018 Feb;48:51-56. doi: 10.1016/j.gde.2017.10.009. Epub 2017 Nov 8.
Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans, which is catalyzed in ADAR enzymes. Recent genomic studies have revealed thousands of altered RNA editing events in various cancer tissues, leading to diverse functional consequences. A critical role of individual A-to-I RNA editing events in cancer has been reported. Here, we review the current state of our knowledge on key A-to-I RNA editing events in coding and non-coding regions for their roles in cancer development and discuss their potential clinical utility. A better understanding of A-to-I RNA editing and its oncogenic mechanisms may facilitate the development of novel cancer therapeutic strategies.
腺嘌呤到次黄嘌呤（A-to-I）RNA 编辑是人类最常见的转录后核苷酸修饰类型，由 ADAR 酶催化。最近的基因组研究揭示了各种癌症组织中数千种改变的 RNA 编辑事件，导致了多种功能后果。已经报道了个体 A-to-I RNA 编辑事件在癌症中的关键作用。在这里，我们回顾了目前关于编码和非编码区域中关键 A-to-I RNA 编辑事件的知识状态，讨论了它们在癌症发展中的作用，并探讨了它们的潜在临床应用。更好地了解 A-to-I RNA 编辑及其致癌机制可能有助于开发新的癌症治疗策略。
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