通过悬浮磁珠链实现基于磁珠的免疫分析的片上信号放大。
On-chip signal amplification of magnetic bead-based immunoassay by aviating magnetic bead chains.
机构信息
Bio IT Convergence Laboratory, Department of Electronic Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Bio IT Convergence Laboratory, Department of Electronic Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
出版信息
Bioelectrochemistry. 2018 Aug;122:221-226. doi: 10.1016/j.bioelechem.2017.11.001. Epub 2017 Nov 6.
In this work, a Lab-on-a-Chip (LOC) platform is used to electromagnetically actuate magnetic bead chains for an enhanced immunoassay. Custom-made electromagnets generate a magnetic field to form, rotate, lift and lower the magnetic bead chains (MBCs). The cost-effective, disposable LOC platform was made with a polymer substrate and an on-chip electrochemical sensor patterned via the screen-printing process. The movement of the MBCs is controlled to improve the electrochemical signal up to 230% when detecting beta-type human chorionic gonadotropin (β-hCG). Thus, the proposed on-chip MBC-based immunoassay is applicable for rapid, qualitative electrochemical point-of-care (POC) analysis.
在这项工作中，我们使用片上实验室（LOC）平台通过电磁作用来驱动磁珠链，以增强免疫分析。定制的电磁体产生磁场以形成、旋转、提升和降低磁珠链（MBC）。这种具有成本效益的、一次性的 LOC 平台由聚合物衬底和通过丝网印刷工艺制成的片上电化学传感器组成。通过控制 MBC 的运动，当检测β-人绒毛膜促性腺激素（β-hCG）时，电化学信号提高了 230%。因此，所提出的基于片上磁珠的免疫分析适用于快速、定性的电化学即时检测（POC）分析。
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