Zierenberg-Ripoll A, Pollard R E, Stewart S L, Allstadt S D, Barrett L E, Gillem J M, Skorupski K A
School of Veterinary Medicine, University of California, Davis, California 95616, USA.
Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, California 95616, USA.
J Small Anim Pract. 2018 Jun;59(6):343-349. doi: 10.1111/jsap.12778. Epub 2017 Nov 14.
To estimate prevalence of exposure to environmental tobacco smoke and other environmental toxins in dogs with primary lung tumours and to analyse association between exposure and lung tumour development.
In this case-control study, an owner survey was developed to collect data on patient characteristics, general health care and environmental exposures. Dogs diagnosed with primary lung carcinomas formed the Case group. Dogs diagnosed with mast cell tumours served as Control Group 1 and dogs diagnosed with neurologic disease served as Control Group 2. Associations between diagnosis of primary lung tumour and patient and environmental exposure variables were analysed using bivariate and multivariate statistical methods.
A total of 1178 owner surveys were mailed and 470 surveys were returned and included in statistical analysis, including 135 Cases, 169 dogs in Control Group 1 and 166 dogs in Control Group 2. An association between exposure to second-hand smoke and prevalence of primary lung cancer was not identified in this study.
Second-hand smoke is associated with primary lung cancer in people but a definitive association has not been found in dogs. The results of this study suggest that tobacco smoke exposure may not be associated with primary lung cancer development in dogs but study limitations may have precluded detection of an association.
评估原发性肺肿瘤犬暴露于环境烟草烟雾及其他环境毒素中的情况，并分析暴露与肺肿瘤发生之间的关联。
在这项病例对照研究中，设计了一份主人调查问卷，以收集有关患犬特征、一般医疗保健及环境暴露的数据。被诊断为原发性肺癌的犬组成病例组。被诊断为肥大细胞瘤的犬作为对照组1，被诊断为神经疾病的犬作为对照组2。采用双变量和多变量统计方法分析原发性肺肿瘤诊断与患犬及环境暴露变量之间的关联。
共邮寄了1178份主人调查问卷，470份问卷被收回并纳入统计分析，其中包括135例病例、169只对照组1的犬和166只对照组2的犬。本研究未发现二手烟暴露与原发性肺癌患病率之间存在关联。
二手烟与人的原发性肺癌有关，但在犬中尚未发现明确的关联。本研究结果表明，烟草烟雾暴露可能与犬原发性肺癌的发生无关，但研究的局限性可能妨碍了关联的检测。
