钴催化的芳基卤代物的铃木偶联反应。
Cobalt-Catalyzed Suzuki Biaryl Coupling of Aryl Halides.
机构信息
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Department of Chemistry and Chemical Engineering, SBA School of Science & Engineering, Lahore University of Management Sciences, Lahore, 54792, Pakistan.
出版信息
Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16367-16370. doi: 10.1002/anie.201710053. Epub 2017 Nov 28.
Abstract
Readily accessed cobalt pre-catalysts with N-heterocyclic carbene ligands catalyze the Suzuki cross-coupling of aryl chlorides and bromides with alkyllithium-activated arylboronic pinacolate esters. Preliminary mechanistic studies indicate that the cobalt species is reduced to Co during the reaction.
摘要
易于获得的带有 N-杂环卡宾配体的钴前催化剂可催化芳基氯代物和溴代物与烷基锂活化的芳基硼酸频哪醇酯的 Suzuki 交叉偶联反应。初步的机理研究表明，在反应过程中钴物种被还原为 Co。
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