Department of Public Health and Infectious Diseases, P.le Aldo Moro 5, 00185, Sapienza University, Rome, Italy.
Department of Chemistry, P.le Aldo Moro 5, 00185, Sapienza University, Rome, Italy.
Sci Total Environ. 2018 Apr 1;619-620:58-64. doi: 10.1016/j.scitotenv.2017.11.090. Epub 2017 Nov 29.
The aims of the present study were to establish reference values useful in monitoring Lithium (Li) treatment and to trace environmental Li exposure profiles in paediatric age. A cross-sectional study was conducted on a group of healthy Italian children aged 5-11. Data on possible predictors were assessed through a questionnaire, and Li levels in morning and evening urinary samples were determined by ICP-MS technique. The reference intervals for the evening and morning samples were respectively 3.8-51.9μgL or 5.6-60.6μgg creatinine and 4.8-71.7μgL or 4.8-73.2μgg creatinine. Urinary Li levels showed a significantly inverse correlation with age and a positive correlation with urinary creatinine in both the evening and morning samples. No other studied variables influenced Li urinary excretion. These results, obtained using a readily available matrix as urine, can be useful for both environmental research and Li treatment monitoring.
本研究的目的是建立有用的参考值，以监测锂 (Li) 治疗，并追踪儿科环境 Li 暴露情况。我们对一组 5-11 岁的健康意大利儿童进行了横断面研究。通过问卷调查评估了可能的预测因素，并用 ICP-MS 技术测定了早晨和晚上尿样中的 Li 水平。晚上和早晨样本的参考区间分别为 3.8-51.9μg/L 或 5.6-60.6μg/g 肌酐和 4.8-71.7μg/L 或 4.8-73.2μg/g 肌酐。尿 Li 水平与年龄呈显著负相关，与早晚两批尿样中的尿肌酐呈正相关。其他研究变量对 Li 尿排泄没有影响。这些结果是使用尿液等易得基质获得的，对环境研究和 Li 治疗监测都很有用。
