Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, P.R. China; Tianjin General Hospital, Tianjin Medical University, Tianjin, P.R. China.
Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, P.R. China.
J Clin Lipidol. 2018 Jan-Feb;12(1):185-192. doi: 10.1016/j.jacl.2017.10.009. Epub 2017 Nov 7.
Despite abundant evidence indicating that higher triglyceride (TG) levels are associated with increased risks of hyperuricemia (HUA), it is unclear whether TG levels can independently predict the incidence of HUA.
The aim of the study was to investigate whether TG is an independent risk factor of HUA in a cohort study.
We explored the relationship between TG levels and HUA in a dynamic cohort established in 2009. During the 6 years of follow-up, 5442 subjects without HUA were studied. We divided subjects into 4 groups based on baseline TG levels and used the Cox hazard regression model to estimate HUA risk by TG quartile, after adjustment for potential confounding factors. Kaplan-Meier survival analysis compared the risk of HUA incidence among individuals in each TG quartile.
The incidence of HUA in this cohort was 25.9%. The hazard ratios (95% confidence intervals) for HUA in the second, third, and fourth TG quartiles, compared with the first quartile, were 1.19 (1.01-1.40), 1.33 (1.13-1.57), and 1.62 (1.37-1.92), respectively. The Kaplan-Meier survival analysis suggested that higher TG levels predicted higher incidences of HUA in a dose-dependent relationship. Stratification analyses showed that the association between TG levels and the presence of HUA was more pronounced in individuals aged <50 years, of obese, with normal estimated glomerular filtration rate, and with hypertension.
Our findings suggest that TG level is a significant and independent risk factor for HUA.
尽管大量证据表明，较高的甘油三酯（TG）水平与高尿酸血症（HUA）的风险增加有关，但 TG 水平是否能独立预测 HUA 的发生尚不清楚。
本研究旨在探讨 TG 是否是队列研究中 HUA 的一个独立危险因素。
我们在 2009 年建立的动态队列中探讨了 TG 水平与 HUA 之间的关系。在 6 年的随访期间，研究了 5442 例无 HUA 的受试者。我们根据基线 TG 水平将受试者分为 4 组，并使用 Cox 风险回归模型，在调整潜在混杂因素后，估计 TG 四分位数与 HUA 风险的关系。Kaplan-Meier 生存分析比较了每个 TG 四分位数个体中 HUA 发生率的风险。
该队列中 HUA 的发生率为 25.9%。与第一四分位相比，第二、第三和第四 TG 四分位的 HUA 风险比（95%置信区间）分别为 1.19（1.01-1.40）、1.33（1.13-1.57）和 1.62（1.37-1.92）。Kaplan-Meier 生存分析表明，TG 水平与 HUA 的发生呈剂量依赖性关系，TG 水平越高，HUA 的发生率越高。分层分析表明，在年龄<50 岁、肥胖、估计肾小球滤过率正常和高血压的个体中，TG 水平与 HUA 的存在之间的关联更为明显。
我们的研究结果表明，TG 水平是 HUA 的一个重要且独立的危险因素。
