Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Experiment Center for Medical Science Research, Kunming Medical University, Kunming, Yunnan, China.
Oxid Med Cell Longev. 2017;2017:1459497. doi: 10.1155/2017/1459497. Epub 2017 Aug 24.
Over the past two decades, obesity has been one of the major public health concerns in most countries. In the search for new molecules that could be used for the treatment of obesity, good perspectives have been opened up for polyphenols, a class of natural bioactive phytochemicals. Experimental and limited clinical trial evidence supports that some polyphenols such as quercetin, curcumin, and resveratrol have potential benefit functions on obesity treatment. This brief review focuses on the main functions of the above-named polyphenols on adipose tissue. These polyphenols may play beneficial effects on adipose tissue under obese condition by alleviating intracellular oxidative stress, reducing chronic low-grade inflammation, inhibiting adipogenesis and lipogenesis, and suppressing the differentiation of preadipocytes to mature adipocytes.
在过去的二十年中，肥胖已成为大多数国家主要的公共卫生关注点之一。在寻找可用于治疗肥胖症的新分子的过程中，多酚类物质——一类天然生物活性植物化学物质，为我们带来了良好的前景。实验和有限的临床试验证据表明，一些多酚类物质，如槲皮素、姜黄素和白藜芦醇，对肥胖症的治疗具有潜在的益处。本文简要综述了上述多酚类物质对脂肪组织的主要功能。这些多酚类物质可以通过减轻细胞内氧化应激、减少慢性低度炎症、抑制脂肪生成和脂生成以及抑制前体脂肪细胞向成熟脂肪细胞的分化，对肥胖状态下的脂肪组织发挥有益作用。
