Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR 06100, Ankara, Turkey.
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, United States.
Anticancer Agents Med Chem. 2018;18(5):667-674. doi: 10.2174/1871520617666171113121246.
The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. Clinical studies have shown beneficial effects of G. lucidum as an alternative adjuvant therapy in cancer patients without obvious toxicity. G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts of this mushroom. Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic effects. Here, we briefly summarize these anticancer effects of GLP and the underlying mechanisms.
灵芝（Ganoderma lucidum）在亚洲国家已经使用了几个世纪，用于治疗各种疾病和促进健康长寿。临床研究表明，灵芝作为癌症患者的辅助治疗方法具有有益的效果，且没有明显的毒性。灵芝多糖（GLP）是这种蘑菇水溶性提取物中的主要生物活性成分。体外和体内研究的证据表明，GLP 通过免疫调节、抗增殖、促凋亡、抗转移和抗血管生成作用具有潜在的抗癌活性。在这里，我们简要总结了 GLP 的这些抗癌作用及其潜在机制。
