Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy -
Unit of Dermatology, IRCCS Ca' Granda, Maggiore Policlinico Hospital, Milan, Italy.
G Ital Dermatol Venereol. 2019 Aug;154(4):466-479. doi: 10.23736/S0392-0488.17.05670-X. Epub 2017 Nov 16.
Primary cutaneous B-cell lymphomas comprehend a group of lymphoproliferative disorders characterized by being monoclonal proliferations of B-cell primarily involving the skin. Despite being recognized as autonomous and distinct clinico-pathologic entities since the late 80s, their classification is still an ongoing matter of debate. At the moment, WHO classification recognizes three disorders: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large b-cell lymphoma (leg type). Primary cutaneous diffuse large b-cell lymphoma (other) has been used to define rare cases which show histologically an infiltrate with diffuse pattern composed by large b-cell, but not fitting with criteria for follicle center lymphoma nor for primary cutaneous diffuse large b-cell lymphoma (leg type). Aim of this review was to briefly describe all recognized and provisional entities included in the primary cutaneous b-cell lymphomas and to discuss recent acquisitions that may influence their future classifications.
原发性皮肤 B 细胞淋巴瘤包括一组以皮肤为主要受累部位的单克隆 B 细胞增殖性疾病。尽管自 80 年代末以来，它们被认为是自主和独特的临床病理实体，但它们的分类仍然存在争议。目前，世界卫生组织（WHO）分类承认三种疾病：原发性皮肤边缘区淋巴瘤、原发性皮肤滤泡中心淋巴瘤和原发性皮肤弥漫性大 B 细胞淋巴瘤（腿型）。原发性皮肤弥漫性大 B 细胞淋巴瘤（其他）用于定义少数病例，这些病例的组织学表现为弥漫性浸润，由大 B 细胞组成，但不符合滤泡中心淋巴瘤或原发性皮肤弥漫性大 B 细胞淋巴瘤（腿型）的标准。本综述的目的是简要描述原发性皮肤 B 细胞淋巴瘤中所有已识别和暂定的实体，并讨论可能影响其未来分类的最新发现。
