Wigner Research Centre for Physics, Hungarian Academy of Sciences, Budapest, Hungary.
Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Elife. 2017 Nov 17;6:e29384. doi: 10.7554/eLife.29384.
Revealing the current source distribution along the neuronal membrane is a key step on the way to understanding neural computations; however, the experimental and theoretical tools to achieve sufficient spatiotemporal resolution for the estimation remain to be established. Here, we address this problem using extracellularly recorded potentials with arbitrarily distributed electrodes for a neuron of known morphology. We use simulations of models with varying complexity to validate the proposed method and to give recommendations for experimental applications. The method is applied to in vitro data from rat hippocampus.
揭示神经元膜上的电流源分布是理解神经计算的关键步骤；然而，实现足够的时空分辨率进行估计的实验和理论工具仍有待建立。在这里，我们使用具有任意分布电极的细胞外记录电势来解决这个问题，这些电极用于已知形态的神经元。我们使用具有不同复杂度的模型的模拟来验证所提出的方法，并为实验应用提供建议。该方法应用于大鼠海马体的体外数据。
