细胞外线粒体在急性中枢神经系统损伤治疗和诊断中的应用。
Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury.
机构信息
Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.
Departments of Critical Care Medicine, Neurology and Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
出版信息
JAMA Neurol. 2018 Jan 1;75(1):119-122. doi: 10.1001/jamaneurol.2017.3475.
OBJECTIVE
Acute central nervous system (CNS) injury after stroke and trauma remains a clinical challenge with limited diagnostic and therapeutic approaches. In this article, we review studies suggesting that after CNS injury, mitochondria can be released into extracellular space as a "help-me" signal to augment recovery. Results are taken from experimental studies in cell and animal models and an initial proof-of-concept analysis in humans suggesting the functional relevance of extracellular mitochondria after acute CNS injury.
OBSERVATIONS
After acute CNS injury, (1) mitochondria may be released into extracellular space, (2) mitochondria may be transferred between cells, and (3) levels of extracellular mitochondria may serve as potential biomarkers for recovery.
CONCLUSIONS AND RELEVANCE
Further translational and clinical studies are warranted to assess the overall hypothesis of using extracellular mitochondria as a therapy and biomarker in the CNS after stroke and trauma.
目的
脑卒中与创伤后急性中枢神经系统（CNS）损伤仍然是一个临床挑战，目前的诊断和治疗方法有限。本文回顾了一些研究，这些研究表明，CNS 损伤后，线粒体可以作为一种“求救”信号释放到细胞外间隙，以促进恢复。这些结果来自细胞和动物模型的实验研究，以及初步的人体概念验证分析，提示急性 CNS 损伤后细胞外线粒体具有功能相关性。
观察结果
急性 CNS 损伤后，（1）线粒体可能会释放到细胞外间隙，（2）线粒体可能在细胞间转移，（3）细胞外线粒体的水平可能作为恢复的潜在生物标志物。
结论和相关性
需要进一步的转化和临床研究来评估将细胞外线粒体作为脑卒中与创伤后 CNS 治疗和生物标志物的总体假设。
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