Imran Aman, Qamar Hafiza Yasara, Ali Qurban, Naeem Hafsa, Riaz Mariam, Amin Saima, Kanwal Naila, Ali Fawad, Sabar Muhammad Farooq, Nasir Idrees Ahmad
Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan.
Iran J Public Health. 2017 Nov;46(11):1475-1485.
Cancer is a genetic disease and mainly arises due to a number of reasons include activation of onco-genes, malfunction of tumor suppressor genes or mutagenesis due to external factors.
This article was written from the data collected from PubMed, Nature, Science Direct, Springer and Elsevier groups of journals.
Oncogenes are deregulated form of normal proto-oncogenes required for cell division, differentiation and regulation. The conversion of proto-oncogene to oncogene is caused due to translocation, rearrangement of chromosomes or mutation in gene due to addition, deletion, duplication or viral infection. These oncogenes are targeted by drugs or RNAi system to prevent proliferation of cancerous cells. There have been developed different techniques of molecular biology used to diagnose and treat cancer, including retroviral therapy, silencing of oncogenes and mutations in tumor suppressor genes.
Among all the techniques used, RNAi, zinc finger nucleases and CRISPR hold a brighter future towards creating a Cancer Free World.
癌症是一种遗传性疾病，主要由多种原因引起，包括癌基因激活、肿瘤抑制基因功能异常或外部因素导致的诱变。
本文依据从PubMed、《自然》《科学Direct》、施普林格和爱思唯尔等期刊集团收集的数据撰写而成。
癌基因是细胞分裂、分化和调控所需的正常原癌基因的失调形式。原癌基因向癌基因的转变是由于染色体易位、重排或基因因添加、缺失、重复或病毒感染而发生突变所致。这些癌基因可被药物或RNA干扰系统靶向，以防止癌细胞增殖。已经开发出了用于诊断和治疗癌症的不同分子生物学技术，包括逆转录病毒疗法、癌基因沉默和肿瘤抑制基因突变。
在所有使用的技术中，RNA干扰、锌指核酸酶和CRISPR在创造无癌世界方面有着更光明的前景。
