帕金森病中的睡眠与昼夜节律障碍
SLEEP AND CIRCADIAN RHYTHM DISORDERS IN PARKINSON'S DISEASE.
作者信息
Gros Priti, Videnovic Aleksandar
机构信息
Division of Neurology, University of Toronto, Toronto, ON, Canada.
Movement Disorders Unit, Division of Sleep Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
出版信息
Curr Sleep Med Rep. 2017 Sep;3(3):222-234. doi: 10.1007/s40675-017-0079-y. Epub 2017 Jul 6.
PURPOSE OF REVIEW
Sleep disorders are among the most challenging non-motor features of Parkinson's disease (PD) and significantly affect quality of life. Research in this field has gained recent interest among clinicians and scientists and is rapidly evolving. This review is dedicated to sleep and circadian dysfunction associated with PD.
RECENT FINDINGS
Most primary sleep disorders may co-exist with PD; majority of these disorders have unique features when expressed in the PD population.
SUMMARY
We discuss the specific considerations related to the common sleep problems in Parkinson's disease including insomnia, rapid eye movement sleep behavior disorder, restless legs syndrome, sleep disordered breathing, excessive daytime sleepiness and circadian rhythm disorders. Within each of these sleep disorders, we present updated definitions, epidemiology, etiology, diagnosis, clinical implications and management. Furthermore, areas of potential interest for further research are outlined.
综述目的
睡眠障碍是帕金森病（PD）最具挑战性的非运动症状之一，对生活质量有显著影响。该领域的研究最近引起了临床医生和科学家的兴趣，并且正在迅速发展。本综述致力于探讨与PD相关的睡眠和昼夜节律功能障碍。
最新发现
大多数原发性睡眠障碍可能与PD共存；这些障碍中的大多数在PD患者群体中表现时具有独特特征。
总结
我们讨论了与帕金森病常见睡眠问题相关的具体考量因素，包括失眠、快速眼动睡眠行为障碍、不宁腿综合征、睡眠呼吸障碍、日间过度嗜睡和昼夜节律障碍。在每种睡眠障碍中，我们介绍了最新的定义、流行病学、病因、诊断、临床意义及管理方法。此外，还概述了有待进一步研究的潜在关注领域。
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