Kabat G C, Wynder E L
Division of Epidemiology, American Health Foundation, New York, NY 10017.
Int J Cancer. 1989 Feb 15;43(2):190-4. doi: 10.1002/ijc.2910430203.
The effect on oral cancer risk of different types of alcoholic beverage was investigated using data from a hospital-based case-control study. Owing to the small numbers of subjects drinking one beverage exclusively, it was necessary to classify drinkers as consumers of predominantly beer, wine, or hard liquor (i.e., more than 50% of their whiskey equivalents of alcohol derived from a specific beverage). The number of predominantly wine drinkers was too small to permit analysis. Logistic regression was used to obtain estimates of the risk associated with each predominant beverage, with adjustment for other risk factors and confounding variables. In males, the odds ratio for predominantly beer drinkers increased with increasing level of intake, reaching 4.87 (95% confidence interval: 2.51-9.46) in drinkers of 7+ oz. of whiskey equivalents/day. The odds ratio for predominantly hard liquor drinkers showed a similar increase, reaching 5.74 (95% confidence interval: 2.94-11.22) in predominantly hard liquor drinkers consuming 7+ oz. of whiskey equivalents/day, suggesting that the effect of these 2 major types of alcoholic beverage is of similar magnitude. The trends were less clearcut in women due to small numbers of drinkers.
利用一项基于医院的病例对照研究数据，对不同类型酒精饮料对口腔癌风险的影响进行了调查。由于仅饮用一种饮料的受试者数量较少，有必要将饮酒者分类为主要饮用啤酒、葡萄酒或烈性酒的人群（即其酒精摄入量中超过50%的威士忌当量来自特定饮料）。主要饮用葡萄酒的人数太少，无法进行分析。采用逻辑回归分析来估计与每种主要饮料相关的风险，并对其他风险因素和混杂变量进行了调整。在男性中，主要饮用啤酒者的比值比随摄入量增加而升高，每天饮用7盎司及以上威士忌当量的啤酒饮用者，其比值比达到4.87（95%置信区间：2.51 - 9.46）。主要饮用烈性酒者的比值比也有类似升高，每天饮用7盎司及以上威士忌当量的主要饮用烈性酒者，其比值比达到5.74（95%置信区间：2.94 - 11.22），这表明这两种主要类型酒精饮料的影响程度相似。由于饮酒者数量较少，女性中的趋势不太明显。
