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本文引用的文献

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Degradation of serum microRNAs during transient storage of serum samples at 4℃.
Ann Clin Biochem. 2018 Jan;55(1):178-180. doi: 10.1177/0004563217704233. Epub 2017 Jun 29.
2
Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation.暴露于电离辐射后血浆外泌体样囊泡中蛋白质和微小RNA含量的定量变化。
Int J Radiat Biol. 2017 Jun;93(6):569-580. doi: 10.1080/09553002.2017.1294772. Epub 2017 Mar 7.
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Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer.高 Gleason 评分前列腺癌患者尿细胞外囊泡的蛋白质组学分析。
Sci Rep. 2017 Feb 17;7:42961. doi: 10.1038/srep42961.
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Characterization of Protein Content Present in Exosomes Isolated from Conditioned Media and Urine.对从条件培养基和尿液中分离出的外泌体中蛋白质含量的表征。
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Differential miRNA expression in pleural effusions derived from extracellular vesicles of patients with lung cancer, pulmonary tuberculosis, or pneumonia.肺癌、肺结核或肺炎患者细胞外囊泡来源的胸腔积液中miRNA的差异表达。
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DNA in serum extracellular vesicles is stable under different storage conditions.血清细胞外囊泡中的DNA在不同储存条件下是稳定的。
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Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer.循环细胞外囊泡上的纤连蛋白作为检测乳腺癌的液体活检手段
Oncotarget. 2016 Jun 28;7(26):40189-40199. doi: 10.18632/oncotarget.9561.
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Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.细胞外囊泡通讯：我们的现状与未来展望。
Cell. 2016 Mar 10;164(6):1226-1232. doi: 10.1016/j.cell.2016.01.043.
9
Extracellular vesicles for drug delivery.细胞外囊泡用于药物递送。
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Integrated Magneto-Electrochemical Sensor for Exosome Analysis.用于外泌体分析的集成磁电化学传感器
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[细胞外囊泡临床应用的进展与分析方法]

[Progress and analysis methods of clinical application of extracellular vesicles].

作者信息

An Tai-Xue, Zheng Lei

机构信息

Department of Laboratory Medicine, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China. E-mail:

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2017 Nov 20;37(11):1559-inside back cover. doi: 10.3969/j.issn.1673-4254.2017.11.23.

DOI:10.3969/j.issn.1673-4254.2017.11.23
PMID:29180342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6779649/
Abstract

Extracellular vesicles (EVs) are small vesicles released by cells, which contain proteins and miRNA. It is a new research field in recent years. EVs change accordingly in a variety of diseases. These vesicles can sensitively reflect the pathological changes of the body. Compared with tissue biopsy, EVs detection have the advantages of non-invasive, simple sampling and real-time monitoring. EVs are becoming new diagnostic marker. This article reviews the current status and progress of EVs in clinical application.

摘要

细胞外囊泡（EVs）是细胞释放的小囊泡，其中含有蛋白质和微小核糖核酸（miRNA）。这是近年来一个新的研究领域。在多种疾病中，EVs会相应地发生变化。这些囊泡能够灵敏地反映机体的病理变化。与组织活检相比，检测EVs具有非侵入性、采样简单和实时监测等优点。EVs正成为新的诊断标志物。本文综述了EVs在临床应用中的现状和进展。