Panahandeh Gholamreza, Vatani Bahareh, Safavi Parvin, Khoshdel Abolfazl
Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
J Adv Pharm Technol Res. 2017 Oct-Dec;8(4):138-142. doi: 10.4103/japtr.JAPTR_45_17.
Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double-blind, randomized clinical trial. In this study, 42 nonanemic children with ADHD and serum ferritin below 30 mg/ml were enrolled according to convenience sampling and randomly assigned to two groups of 21 each, cases and controls. The two groups were matched for age and sex. The case group was administered with ferrous sulfate 5 mg/kg in addition to methylphenidate up to 1 mg/kg and the control group with methylphenidate alone. The scores on child symptoms inventory-4 (CSI-4) were recorded at baseline and after 2 months of treatment. Data were analyzed by -test, Pearson's correlation coefficient, and repeated measures ANOVA in SPSS 16. The scores on CSI-4 decreased significantly at month 2 in both groups ( < 0.001). The scores on attention deficit and hyperactivity subscales of the CSI-4 were significantly lower in the case group than the control group ( < 0.05). The total score on CSI-4 decreased more markedly in the case group ( < 0.04). Use of ferrous sulfate plus methylphenidate can be effective in reducing ADHD symptoms in nonanemic children with low serum ferritin.
注意缺陷多动障碍（ADHD）是儿童中最常见的精神疾病之一，会引发多种并发症。本研究旨在探讨硫酸亚铁联合哌甲酯对减轻ADHD症状的效果。本研究为双盲随机临床试验。在本研究中，通过便利抽样纳入42名非贫血型ADHD儿童，其血清铁蛋白低于30mg/ml，并随机分为两组，每组21人，分别为病例组和对照组。两组在年龄和性别上相匹配。病例组除接受最高1mg/kg的哌甲酯治疗外，还给予5mg/kg的硫酸亚铁，对照组仅接受哌甲酯治疗。在基线期和治疗2个月后记录儿童症状量表-4（CSI-4）的得分。数据在SPSS 16中通过t检验、Pearson相关系数和重复测量方差分析进行分析。两组在第2个月时CSI-4得分均显著下降（P<0.001）。病例组CSI-4注意力缺陷和多动子量表的得分显著低于对照组（P<0.05）。病例组CSI-4总分下降更为明显（P<0.04）。硫酸亚铁联合哌甲酯可有效减轻血清铁蛋白水平低的非贫血型儿童的ADHD症状。
