Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC, 28081, United States; School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC, 28081, United States; Department of Food, Bioprocessing & Nutrition Sciences, North Carolina State University, 400 Dan Allen Drive, Raleigh, NC, 27695, United States.
Food Chem Toxicol. 2018 Jan;111:445-453. doi: 10.1016/j.fct.2017.11.032. Epub 2017 Nov 28.
Driven by the need for alternative whole food options to manage metabolic syndrome, multiple dietary interventions are suggested to achieve a better control of metabolic risk factors and molecular networks that regulate cellular energy metabolism. It is generally accepted that anthocyanin-rich diets are beneficial for maintaining healthy body weight, improving glucose and lipid metabolism, and determining inflammatory status of key metabolic tissues. However, anthocyanins are a structurally diverse group of phenolic compounds and their individual contributions to improving metabolic health are not clear. In this study, we show that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. Blueberries and Concord grapes (57% and 33% anthocyanins as malvidin, petunidin, or peonidin, respectively) improved body composition through individual significant effects on energy expenditure and increased activity. Methylated anthocyanins are also more effective at enhancing mitochondrial respiration and dissipation of the mitochondrial proton gradient (proton leak) in adipose tissue, thus counteracting mitochondrial dysfunction associated with metabolic stress. Together, these results provide direct proof of the higher protective potential of methylated anthocyanins against the metabolic consequences of chronic exposure to calorie-dense foods.
为了寻找替代的全食物来治疗代谢综合征，人们提出了多种饮食干预措施，以更好地控制代谢风险因素和调节细胞能量代谢的分子网络。人们普遍认为，富含花青素的饮食有益于维持健康的体重、改善葡萄糖和脂质代谢，并决定关键代谢组织的炎症状态。然而，花青素是一个结构多样的酚类化合物群体，它们对改善代谢健康的个体贡献尚不清楚。在这项研究中，我们表明，食用具有增强甲基化特征的浆果（矢车菊素和锦葵色素），在多基因肥胖的 C57BL/6 小鼠模型中，更能有效减少高脂肪饮食引起的代谢损伤。蓝莓和康科德葡萄（分别含有 57%和 33%的矢车菊素、锦葵色素或飞燕草素）通过对能量消耗和活动量的单独显著影响，改善了身体成分。甲基化花青素还能更有效地增强脂肪组织中线粒体呼吸和质子梯度（质子渗漏）的耗散，从而抵抗与代谢应激相关的线粒体功能障碍。总之，这些结果为甲基化花青素对慢性摄入高热量食物的代谢后果的更高保护潜力提供了直接证据。
