Mungan Zeynel, Pınarbaşı Şimşek Binnur
Department of Gastroenterology, Koç University School of Medicine, İstanbul, Turkey
Department of Gastroenterology, İstinye University School of Medicine, İstanbul, Turkey
Turk J Gastroenterol. 2017 Dec;28(Suppl 1):S38-S43. doi: 10.5152/tjg.2017.11.
Gastroesophageal reflux disease (GERD), which is common in many communities, is associated with structural factors, eating habits, and the use of certain drugs. The use of such drugs can lead to the emergence of GERD and can also exacerbate existing reflux symptoms. These drugs can contribute to GERD by directly causing mucosal damage, by reducing lower esophageal sphincter pressure (LESP), or by affecting esophagogastric motility. In this article, we report our investigation of the relationships between GERD and medications within the scope of the "Turkish GERD Consensus Group." For the medication groups for which sufficient data were obtained (Figure 1), a systematic literature review in English was conducted using the keywords "gastroesophageal reflux" [MeSH Terms] and "anti-inflammatory agents, non-steroidal" [MeSH Terms], "gastroesophageal reflux" [MeSH Terms] and "acetylsalicylic acid" [MeSH Terms], "gastroesophageal reflux" [All Fields] and "estrogenic agents" [All Fields], "gastroesophageal reflux" [All Fields] and "progesterones" [All Fields], "gastroesophageal reflux" [All Fields] and "hormone replacement therapy" [All Fields], "gastroesophageal reflux" [MeSH Terms] and "diphosphonates" [MeSH Terms] OR "diphosphonates" [All Fields], "calcium channel blockers" [MeSH Terms] and "gastroesophageal reflux" [MeSH Terms], "gastroesophageal reflux" [MeSH Terms] and "nitrates" [MeSH Terms], "gastroesophageal reflux" [MeSH Terms] and "antidepressive agents" [MeSH Terms], "gastroesophageal reflux" [MeSH Terms] and "benzodiazepines" [MeSH Terms] and "hypnotic drugs" [MeSH Terms], "gastroesophageal reflux" [MeSH Terms] and "cholinergic antagonists" [MeSH Terms], "gastroesophageal reflux" [MeSH Terms] and "theophylline" [MeSH Terms], and "gastroesophageal reflux [MeSH Terms] AND "anti-asthmatic agents" [MeSH Terms]. The studies were analyzed and the results are presented here.
胃食管反流病（GERD）在许多群体中都很常见，它与结构因素、饮食习惯以及某些药物的使用有关。使用这类药物可导致GERD的出现，也会加重现有的反流症状。这些药物可通过直接造成黏膜损伤、降低食管下括约肌压力（LESP）或影响食管胃动力而导致GERD。在本文中，我们报告了在“土耳其GERD共识小组”范围内对GERD与药物之间关系的调查。对于获得了充分数据的药物组（图1），使用关键词“胃食管反流”[医学主题词]和“抗炎药，非甾体类”[医学主题词]、“胃食管反流”[医学主题词]和“阿司匹林”[医学主题词]、“胃食管反流”[所有字段]和“雌激素类药物”[所有字段]、“胃食管反流”[所有字段]和“孕激素类”[所有字段]、“胃食管反流”[所有字段]和“激素替代疗法”[所有字段]、“胃食管反流”[医学主题词]和“双膦酸盐类”[医学主题词]或“双膦酸盐类”[所有字段]、“钙通道阻滞剂”[医学主题词]和“胃食管反流”[医学主题词]、“胃食管反流”[医学主题词]和“硝酸盐类”[医学主题词]、“胃食管反流”[医学主题词]和“抗抑郁药”[医学主题词]、“胃食管反流”[医学主题词]和“苯二氮䓬类”[医学主题词]及“催眠药”[医学主题词]、“胃食管反流”[医学主题词]和“胆碱能拮抗剂”[医学主题词]、“胃食管反流”[医学主题词]和“茶碱”[医学主题词]以及“胃食管反流[医学主题词]与“抗哮喘药”[医学主题词]进行了英文系统文献综述。对这些研究进行了分析并在此展示结果。
