L.B.S. College of Pharmacy, Tilak Nagar, Jaipur, India.
Indian J Pharmacol. 2010 Apr;42(2):70-3. doi: 10.4103/0253-7613.64493.
To study the antidiabetic activity of Barleria prionitis Linn in normal and alloxan-induced diabetic rats.
Alcoholic extract of leaf and root of B. prionitis was tested for their antidiabetic activity. Albino rats were divided into six groups of six animals each. In three groups, diabetes was induced using alloxan monohydrate (150 mg/kg b.w., i.p.) and all the rats were given different treatments consisting of vehicle, alcoholic extract of leaves, and alcoholic extract roots of B. prionitis Linn (200 mg/kg) for 14 days. The same treatment was given to the other three groups, comprising non-diabetic (normal) animals. Blood glucose level, glycosylated hemoglobin, liver glycogen, serum insulin, and body weight were estimated in normal and alloxan-induced diabetic rats, before and 2 weeks after administration of drugs.
Animals treated with the alcoholic extract of leaves of B. prionitis Linn showed a significant decrease in blood glucose level (P<0.01) and glycosylated hemoglobin (P<0.01). A significant increase was observed in serum insulin level (P<0.01) and liver glycogen level (P<0.05), whereas the decrease in the body weight was arrested by administration of leaf extract to the animals. The alcoholic extract of roots showed a moderate but non-significant antidiabetic activity in experimental animals.
The study reveals that the alcoholic leaf extract of B. prionitis could be added in the list of herbal preparations beneficial in diabetes mellitus.
研究 Barleria prionitis Linn 在正常和链脲佐菌素诱导的糖尿病大鼠中的抗糖尿病活性。
测试了 Barleria prionitis 的叶和根的醇提物的抗糖尿病活性。将白化大鼠分为 6 组，每组 6 只。在 3 组中，使用一水合链脲霉素（150 mg/kg b.w.，ip）诱导糖尿病，所有大鼠接受不同的治疗，包括载体、Barleria prionitis Linn 的叶醇提物和根醇提物（200 mg/kg），共 14 天。另外 3 组接受相同的治疗，包括非糖尿病（正常）动物。在给药前和给药后 2 周，测定正常和链脲佐菌素诱导的糖尿病大鼠的血糖水平、糖化血红蛋白、肝糖原、血清胰岛素和体重。
用 Barleria prionitis Linn 的叶醇提物治疗的动物的血糖水平（P<0.01）和糖化血红蛋白（P<0.01）显著降低。观察到血清胰岛素水平（P<0.01）和肝糖原水平（P<0.05）显著增加，而给予叶提取物可阻止动物体重下降。根的醇提物在实验动物中表现出适度但非显著的抗糖尿病活性。
研究表明，Barleria prionitis 的叶醇提物可以添加到有益于糖尿病的草药制剂列表中。
