Chen J L, Blanc P, Stoddart C A, Bogan M, Rozhon E J, Parkinson N, Ye Z, Cooper R, Balick M, Nanakorn W, Kernan M R
Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080, USA.
J Nat Prod. 1998 Oct;61(10):1295-7. doi: 10.1021/np980086y.
Two new iridoid glycosides (1 and 2), together with the known compounds barlerin (3) and verbascoside (4), were isolated from Barleria prionitis. The new iridoid glycosides were determined to be 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester (1) and its cis isomer (2) by using spectroscopic, especially 2D NMR, data. A 3:1 mixture of 1 and 2 was shown to have potent in vitro activity against respiratory syncytial virus (EC50 2.46 microgram/mL, IC50 42.2 microgram/mL).
从刺蕊草中分离出两种新的环烯醚萜苷（1和2），以及已知化合物巴莱林（3）和毛蕊花糖苷（4）。通过光谱数据，尤其是二维核磁共振数据，确定新的环烯醚萜苷为6-O-反式对香豆酰基-8-O-乙酰山栀苷甲酯（1）及其顺式异构体（2）。1和2的3:1混合物显示出对呼吸道合胞病毒具有强大的体外活性（半数有效浓度为2.46微克/毫升，半数抑制浓度为42.2微克/毫升）。
