肥胖和超重个体的执行功能表现:荟萃分析和综述。
Executive function performance in obesity and overweight individuals: A meta-analysis and review.
机构信息
The Lab of Mental Health and Social Adaptation, Faculty of Psychology, Research Center of Mental Health Education, Southwest University, Chongqing, China.
Department of Psychology, University of California, Davis, CA, USA.
出版信息
Neurosci Biobehav Rev. 2018 Jan;84:225-244. doi: 10.1016/j.neubiorev.2017.11.020. Epub 2017 Dec 7.
Prior research has suggested that obesity/overweight may be associated with deficits in executive function. If true, this has important clinical implications. In this review, we synthesize the current literature by conducting a meta-analysis of studies comparing executive functions in overweight/obese individuals to normal weight controls. We identified 72 studies-with 4904 overweight/obese participants-that met our inclusion criteria. Effect sizes were analyzed using the robust variance estimation random effects meta-regression technique. It was found that obese participants showed broad impairments on executive function, including on tasks primarily utilizing inhibition, cognitive flexibility, working memory, decision-making, verbal fluency, and planning; overweight participants only showed significant deficits in inhibition and working memory. The only moderator of effects of obesity to emerge significant was the task used to assess the respective executive function, which moderated effects of obesity on working memory and decision-making. There were not enough studies of overweight individuals to make strong claims about moderating effects in those studies. In sum, current evidence supports the existence of broad executive function deficits in obese individuals, and inhibition and working memory deficits in overweight individuals.
先前的研究表明,肥胖/超重可能与执行功能缺陷有关。如果这是真的,那么这具有重要的临床意义。在这篇综述中,我们通过对比较超重/肥胖个体与正常体重对照组执行功能的研究进行荟萃分析,综合了当前的文献。我们确定了 72 项研究,其中包括 4904 名超重/肥胖参与者,这些研究符合我们的纳入标准。使用稳健方差估计随机效应荟萃回归技术分析了效应大小。结果发现,肥胖参与者在执行功能方面表现出广泛的缺陷,包括主要利用抑制、认知灵活性、工作记忆、决策、言语流畅性和计划的任务;超重参与者仅在抑制和工作记忆方面表现出明显的缺陷。唯一显著的肥胖效应调节因素是用于评估各自执行功能的任务,该因素调节了肥胖对工作记忆和决策的影响。超重个体的研究数量不足,无法对这些研究中的调节效应做出有力的论断。总之,目前的证据支持肥胖个体存在广泛的执行功能缺陷,以及超重个体存在抑制和工作记忆缺陷。