S Mariotto, A Farinazzo, S Monaco, A Gajofatto, G Zanusso, K Schanda, R Capra, C Mancinelli, A Bonora, R Bombardi, M Reindl, S Ferrari
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy.
Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Mult Scler J Exp Transl Clin. 2017 Nov 22;3(4):2055217317743098. doi: 10.1177/2055217317743098. eCollection 2017 Oct-Dec.
Neurofilament light chain (NF-L) levels reflect axonal damage in different conditions, including demyelinating disorders.
We aimed to compare serum NF-L levels in patients with aquaporin-4 antibodies (AQP4-Ab), myelin oligodendrocyte antibodies (MOG-Ab) and seronegative cases with neuromyelitis optica spectrum disorders and related disorders.
We analysed AQP4-Ab and MOG-Ab with cell-based assay and NF-L with ultrasensitive electrochemiluminescence immunoassay.
Median NF-L levels were increased in 25 AQP4-Ab-positive patients (59 pg/ml) as compared with 22 MOG-Ab-positive cases (25 pg/ml), 52 seronegative patients (18 pg/ml), 25 multiple sclerosis patients (12 pg/ml) and 14 healthy controls (12 pg/ml).
Increased serum levels of NF-L in patients with AQP4-Ab or MOG-Ab might reflect an ongoing axonal damage and a more malignant disease course.
神经丝轻链（NF-L）水平反映了包括脱髓鞘疾病在内的不同情况下的轴突损伤。
我们旨在比较水通道蛋白4抗体（AQP4-Ab）、髓鞘少突胶质细胞糖蛋白抗体（MOG-Ab）阳性患者以及视神经脊髓炎谱系障碍及相关疾病血清学阴性患者的血清NF-L水平。
我们采用基于细胞的检测方法分析AQP4-Ab和MOG-Ab，采用超灵敏电化学发光免疫分析法检测NF-L。
25例AQP4-Ab阳性患者的NF-L水平中位数（59 pg/ml）高于22例MOG-Ab阳性患者（25 pg/ml）、52例血清学阴性患者（18 pg/ml）、25例多发性硬化症患者（12 pg/ml）和14例健康对照者（12 pg/ml）。
AQP4-Ab或MOG-Ab阳性患者血清NF-L水平升高可能反映了持续的轴突损伤和更恶性的病程。
