Aberdeen Fungal Group, Medical Research Council Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Int J Mol Sci. 2017 Dec 6;18(12):2631. doi: 10.3390/ijms18122631.
The ZIP (Zrt/Irt-like protein) family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution, or their origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, . Pan-domain analysis of bacterial, archaeal, fungal, and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers, (ii) a fungal-specific group of zinc importers having genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal, and eukaryotic phyla.
ZIP（Zrt/Irt-like protein）家族的锌转运蛋白存在于所有三个生命领域。然而，关于 ZIP 转运蛋白的系统发育关系、它们的分布或起源知之甚少。在这里，我们采用系统发育分析来探索 ZIP 转运蛋白的进化，重点是主要的人类真菌病原体 。对细菌、古菌、真菌和人类蛋白质的泛域分析揭示了 ZIP 家族成员之间复杂的关系。在这里，我们报告了（i）一个真核生物广泛的细胞锌内流体组，（ii）一个真菌特有的锌内流体组，与真菌的锌载体具有遗传关联，以及，（iii）一个由两个不同亚群组成的泛界超级群，在细菌、古菌和真核生物门中有同源物。
