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松果菊苷通过抑制氧化应激、DNA 损伤和细胞凋亡缓解 UVB 辐射介导的皮肤损伤。

Echinacoside Alleviates UVB Irradiation-Mediated Skin Damage via Inhibition of Oxidative Stress, DNA Damage, and Apoptosis.

机构信息

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

Department of Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.

出版信息

Oxid Med Cell Longev. 2017;2017:6851464. doi: 10.1155/2017/6851464. Epub 2017 Oct 26.

DOI:10.1155/2017/6851464
PMID:29213352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5682084/
Abstract

Ultraviolet B (UVB) irradiation has been known to cause skin damage, which is associated with oxidative stress, DNA damage, and apoptosis. Echinacoside is a phenylethanoid glycoside isolated from , which exhibits strong antioxidant activity. In this study, we evaluate the photoprotective effect of echinacoside on UVB-induced skin damage and explore the potential molecular mechanism. BALB/c mice and HaCaT cells were treated with echinacoside before UVB exposure. Histopathological examination was used to evaluate the skin damage. Cell viability, lactate dehydrogenase (LDH) levels, antioxidant enzyme activities, reactive oxygen species (ROS) generation, DNA damage, and apoptosis were measured as well. Western blot was used to measure the expression of related proteins. The results revealed that pretreatment of echinacoside ameliorated the skin injury; attenuated oxidative stress, DNA damage, and apoptosis caused by UVB exposure; and normalized the protein levels of ATR, p53, PIAS3, hnRNP K, PARP, and XPA. To summarize, echinacoside is beneficial in the prevention of UVB-induced DNA damage and apoptosis of the skin

摘要

紫外线 B（UVB）照射已知会导致皮肤损伤，这与氧化应激、DNA 损伤和细胞凋亡有关。松果菊苷是一种从 中分离出的苯乙醇苷，具有很强的抗氧化活性。在这项研究中，我们评估了松果菊苷对 UVB 诱导的皮肤损伤的光保护作用，并探讨了其潜在的分子机制。BALB/c 小鼠和 HaCaT 细胞在暴露于 UVB 之前用松果菊苷处理。组织病理学检查用于评估皮肤损伤。还测量了细胞活力、乳酸脱氢酶 (LDH) 水平、抗氧化酶活性、活性氧 (ROS) 生成、DNA 损伤和细胞凋亡。Western blot 用于测量相关蛋白的表达。结果表明，松果菊苷预处理可改善皮肤损伤；减轻 UVB 暴露引起的氧化应激、DNA 损伤和细胞凋亡；并使 ATR、p53、PIAS3、hnRNP K、PARP 和 XPA 的蛋白水平正常化。总之，松果菊苷有利于预防 UVB 诱导的皮肤 DNA 损伤和细胞凋亡。

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