Zhang Tao, Yang Xiaowen, Liu Pei, Zhou Jianrui, Luo Jie, Wang Hui, Li Anrong, Zhou Yi
Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
Department of Clinical Laboratory, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
Oncotarget. 2017 Oct 11;8(60):102486-102498. doi: 10.18632/oncotarget.21829. eCollection 2017 Nov 24.
Although studies have examined the association between nonsteroidal anti-inflammatory drugs (NSAIDs) use and central nervous system (CNS) tumors risk, the results are inconclusive. Here, we conducted a dose-response meta-analysis in order to investigate the correlation between NSAIDs use and CNS tumors risk. Up to July 2017, 12 studies were included in current meta-analysis. NSAIDs use was significantly associated with a lower risk of CNS tumors. Furthermore, non-aspirin NSAIDs or aspirin use are significantly associated with a lower risk of CNS tumors. Additionally, NSAIDs use was associated with significantly a lower risk of glioma, glioblastoma but not meningioma. Subgroup analysis showed consistent findings. Furthermore, a significant dose-response relationship was observed between NSAIDs use and CNS tumors risk. Increasing cumulative 100 defined daily dose of NSAIDs use was associated with a 5% decrement of CNS tumors risk, increasing NSAIDs or non-aspirin NSAIDs or aspirin use (per 3 prescriptions increment) was associated with a 7%, 7%, 10% decrement of CNS tumors risk, increasing per 2 year of duration of NSAIDs or non-aspirin NSAIDs or aspirin use was associated with a 6%, 8%, 6% decrement of CNS tumors risk. Considering these promising results, NSAIDs use might provide helpful for reducing CNS tumors risk. Large sample size and different ethnic population are warranted to validate this association.
尽管已有研究探讨了非甾体抗炎药（NSAIDs）的使用与中枢神经系统（CNS）肿瘤风险之间的关联，但其结果尚无定论。在此，我们进行了一项剂量反应荟萃分析，以研究NSAIDs的使用与CNS肿瘤风险之间的相关性。截至2017年7月，本荟萃分析纳入了12项研究。NSAIDs的使用与较低的CNS肿瘤风险显著相关。此外，非阿司匹林类NSAIDs或阿司匹林的使用与较低的CNS肿瘤风险显著相关。此外，NSAIDs的使用与较低的胶质瘤、胶质母细胞瘤风险相关，但与脑膜瘤风险无关。亚组分析显示了一致的结果。此外，在NSAIDs的使用与CNS肿瘤风险之间观察到显著的剂量反应关系。NSAIDs使用的累积100限定日剂量增加与CNS肿瘤风险降低5%相关，NSAIDs或非阿司匹林类NSAIDs或阿司匹林使用量增加（每增加3张处方）与CNS肿瘤风险降低7%、7%、10%相关，NSAIDs或非阿司匹林类NSAIDs或阿司匹林使用持续时间每增加2年与CNS肿瘤风险降低6%、8%、6%相关。考虑到这些有前景的结果，NSAIDs的使用可能有助于降低CNS肿瘤风险。需要大样本量和不同种族人群来验证这种关联。
