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2
Non-steroidal anti-inflammatory drugs and the risk of head and neck cancer: A case-control analysis.非甾体抗炎药与头颈部癌症风险：病例对照分析。
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Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies.阿司匹林使用与癌症风险的关联：观察性研究的荟萃分析。
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本文引用的文献

1
Aspirin and cancer risk: a quantitative review to 2011.阿司匹林与癌症风险：2011 年前的定量综述。
Ann Oncol. 2012 Jun;23(6):1403-15. doi: 10.1093/annonc/mds113. Epub 2012 Apr 19.
2
Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer: a systematic review.非甾体抗炎药和阿司匹林的使用与头颈部癌症风险：系统评价。
Cancer Causes Control. 2011 May;22(5):803-10. doi: 10.1007/s10552-011-9751-6. Epub 2011 Mar 17.
3
Oropharyngeal cancer epidemic and human papillomavirus.口咽癌流行与人类乳头瘤病毒。
Emerg Infect Dis. 2010 Nov;16(11):1671-7. doi: 10.3201/eid1611.100452.
4
Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials.阿司匹林对结直肠癌发病率和死亡率的长期影响：五项随机试验的 20 年随访。
Lancet. 2010 Nov 20;376(9754):1741-50. doi: 10.1016/S0140-6736(10)61543-7. Epub 2010 Oct 21.
5
Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs.使用非甾体抗炎药的人群患头颈部鳞状细胞癌的风险降低。
Int J Otolaryngol. 2010;2010:424161. doi: 10.1155/2010/424161. Epub 2010 Jun 3.
6
Aspirin, salicylates, and cancer.阿司匹林、水杨酸盐与癌症。
Lancet. 2009 Apr 11;373(9671):1301-9. doi: 10.1016/S0140-6736(09)60243-9. Epub 2009 Mar 26.
7
Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange.环氧化酶-2转录受人类乳头瘤病毒16型E6和E7癌蛋白调控：共抑制因子/共激活因子交换的证据
Cancer Res. 2007 Apr 15;67(8):3976-85. doi: 10.1158/0008-5472.CAN-06-4273.
8
Cyclo-oxygenase-2 and its inhibition in cancer: is there a role?环氧化酶-2及其在癌症中的抑制作用：有作用吗？
Drugs. 2007;67(6):821-45. doi: 10.2165/00003495-200767060-00001.
9
Alcohol and head and neck cancer risk in a prospective study.一项前瞻性研究中的酒精与头颈癌风险
Br J Cancer. 2007 May 7;96(9):1469-74. doi: 10.1038/sj.bjc.6603713. Epub 2007 Mar 27.
10
Chemoprevention of head and neck cancer with aspirin: a case-control study.阿司匹林对头颈部癌症的化学预防：一项病例对照研究。
Arch Otolaryngol Head Neck Surg. 2006 Nov;132(11):1231-6. doi: 10.1001/archotol.132.11.1231.

非甾体抗炎药和阿司匹林的使用与头颈部癌症的风险。

Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer.

机构信息

School of Medicine Dentistry and Biomedical Sciences, Institute of Clinical Sciences, Queen's University Belfast, Belfast, UK.

出版信息

Br J Cancer. 2013 Mar 19;108(5):1178-81. doi: 10.1038/bjc.2013.73. Epub 2013 Feb 28.

DOI:10.1038/bjc.2013.73
PMID:23449358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3619083/
Abstract

BACKGROUND

Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.

METHODS

Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.

RESULTS

Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use.

CONCLUSION

Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.

摘要

背景

非甾体抗炎药（NSAIDs）预防头颈部癌症（HNC）的证据尚无定论；然而，有一些证据表明阿司匹林可能具有保护作用。

方法

利用美国国家癌症研究所前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验的数据，我们研究了阿司匹林和布洛芬的使用与 HNC 之间的关联。

结果

定期使用阿司匹林与 HNC 风险降低 22%显著相关。定期使用布洛芬与 HNC 风险无关。

结论

阿司匹林可能具有预防 HNC 的潜力，但需要进一步研究。