非甾体抗炎药和阿司匹林的使用与头颈部癌症的风险。
Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer.
机构信息
School of Medicine Dentistry and Biomedical Sciences, Institute of Clinical Sciences, Queen's University Belfast, Belfast, UK.
出版信息
Br J Cancer. 2013 Mar 19;108(5):1178-81. doi: 10.1038/bjc.2013.73. Epub 2013 Feb 28.
Abstract
BACKGROUND
Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.
METHODS
Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.
RESULTS
Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use.
CONCLUSION
Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.
摘要
背景
非甾体抗炎药（NSAIDs）预防头颈部癌症（HNC）的证据尚无定论；然而，有一些证据表明阿司匹林可能具有保护作用。
方法
利用美国国家癌症研究所前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验的数据，我们研究了阿司匹林和布洛芬的使用与 HNC 之间的关联。
结果
定期使用阿司匹林与 HNC 风险降低 22%显著相关。定期使用布洛芬与 HNC 风险无关。
结论
阿司匹林可能具有预防 HNC 的潜力，但需要进一步研究。
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