Samarghandian Saeed, Borji Abasalt, Farkhondeh Tahereh
1 Neyshabur University of Medical Sciences, Neyshabur, Iran.
2 Mashhad University of Medical Sciences, Mashhad, Iran.
J Evid Based Complementary Altern Med. 2017 Oct;22(4):562-566. doi: 10.1177/2156587217692491. Epub 2017 Feb 21.
The present study was designed to investigate the protective effect of the aqueous extract of Portulaca oleracea against hyperglycemic, oxidative damage and inflammation in the serum of streptozotocin (STZ)-induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 Portulaca oleracea (100, 200, 400 mg/kg/d)-treated diabetic groups. At the end of the 4-week period, glucose, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), glutathione (GSH), and total antioxidant status (TAS) levels were measured. STZ caused an elevation in the serum levels of glucose, MDA, IL-6, and TNF-α with reduction in the levels of GSH and TAS ( P < .01). Portulaca oleracea ameliorated glucose, MDA, IL-6, TNF-α, GSH, and TAS levels in diabetic groups versus to the untreated groups ( P < .05). Taken together, Portulaca oleracea prevented hyperglycemia by preventing the oxidative stress and inflammation.
本研究旨在探讨马齿苋水提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠血清中高血糖、氧化损伤和炎症的保护作用。在本研究中，将大鼠分为以下几组，每组8只动物：对照组、未治疗的糖尿病组、3个马齿苋（100、200、400 mg/kg/d）治疗的糖尿病组。在4周实验期结束时，测量血糖、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）、谷胱甘肽（GSH）和总抗氧化状态（TAS）水平。STZ导致血清中葡萄糖、MDA、IL-6和TNF-α水平升高，同时GSH和TAS水平降低（P <.01）。与未治疗组相比，马齿苋改善了糖尿病组的葡萄糖、MDA、IL-6、TNF-α、GSH和TAS水平（P <.05）。综上所述，马齿苋通过预防氧化应激和炎症来预防高血糖。
