Center for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan 44919, Korea.
Molecules. 2017 Dec 11;22(12):2197. doi: 10.3390/molecules22122197.
The cell membrane has gained significant attention as a platform for the development of bio-inspired nanodevices due to its immune-evasive functionalities and copious bio-analogs. This review will examine several uses of cell membranes such as (i) therapeutic delivery carriers with or without substrates (i.e., nanoparticles and artificial polymers) that have enhanced efficiency regarding copious cargo loading and controlled release, (ii) exploiting nano-bio interfaces in membrane-coated particles from the macro- to the nanoscales, which would help resolve the biomedical issues involved in biological interfacing in the body, and (iii) its effects on the mobility of bio-moieties such as lipids and/or proteins in cell membranes, as discussed from a biophysical perspective. We anticipate that this review will influence both the development of novel anti-phagocytic delivery cargo and address biophysical problems in soft and complex cell membrane.
细胞膜因其免疫逃避功能和丰富的生物类似物而成为生物启发型纳米器件发展的重要平台。本综述将考察细胞膜的几种用途，例如 (i) 具有或不具有基质（即纳米颗粒和人工聚合物）的治疗性递药载体，在大量货物负载和控制释放方面具有更高的效率，(ii) 利用从宏观到纳米尺度的膜包裹颗粒中的纳米生物界面，这将有助于解决涉及生物体内生物界面的生物医学问题，以及 (iii) 从生物物理角度讨论其对细胞膜中生物分子（如脂质和/或蛋白质）迁移率的影响。我们预计，本综述将影响新型抗吞噬递药载体的开发，并解决软质复杂细胞膜中的生物物理问题。
